Protein Alignment dos and Phldb1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_030099813.2
• Gene: Phldb1 / 102693
• MGIID: 2143230
• Length: 1642
• Species: Mus musculus
• Alignment Length: 900
• Identity: 182/900 - (20%)
• Similarity: 282/900 - (31%)
• Gaps: 300/900 - (33%)

  Fly   124 PLGAVGADENRTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVP-------------NAGGS 175
            |...|.|:..||..:...||  .......:.|.:.|:|..:..||:|             |..|:
Mouse   434 PAATVLAEARRTTESPRLGG--QLPVVAISLSEYPSSGARSQPASIPGSPKFQSPVPAPRNKIGT 496

  Fly   176 AQLRRPAVIEEQP--------MPSN--AGNNNSDSVYVNTEYSNRETMLCDANFDQQELLSAAQQ 230
            .|.|.|:...|.|        .||.  .|...||.:.........|:....     :..|.:.::
Mouse   497 LQDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPESPRLG-----RRGLDSMRE 556

  Fly   231 QPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAAR-LAVSANGVVRKLPEHLVLT------ 288
            .||.||:    |:..||....|..|...:|.::..::.| ...:|:|.   .||...||
Mouse   557 LPPLSPS----LSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGT---SPEDFSLTLGARGR 614

  Fly   289 -----QQTLAEAAAQQHSSV--QASPALSTASGPYIPISECFSGSPRFLPGV--PLPGADLAIP- 343
                 ..||.|:.|.:..|.  :.|||.|..|        ....|||..|..  .|...||.:|
Mouse   615 RTRSPSPTLGESLAPRKGSFSGRLSPAYSLGS--------LTGASPRQSPRAQRKLSSGDLRVPI 671

  Fly   344 ----NNPTTPLNNLDPKFYD-----------------TPRSHNNIGLNLTNDQSYS---PKITNL 384
                .|..|.:::.:.:..:                 ..|......|||..:.|.:   |:...|
Mouse   672 PRERKNSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPETGEL 736

  Fly   385 -------SLQQLANNNASK---------------------------QRSD--------SDSES-- 405
                   :...||....|:                           :|||        |.:||
Mouse   737 PSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMERSDEENLKEECSSTESTQ 801

  Fly   406 --------------VFTDDDEWAHPL-----------PLRENVDRSTRPSD-------------- 431
                          |...::|.|..|           .|.:.:..:.|.::
Mouse   802 QEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQQLQEAAREAEMERALLQGEREAER 866

  Fly   432 SSIENESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASL-----------------PEAGDQ 479
            :|::.|...:...|......|.|.......|::...||...|                 ||:..:
Mouse   867 ASLQKEQRAVDQLQEKLVALETGIQKDRDKERAELAAGRRHLEARQALYAELQTQLDNCPESVRE 931

  Fly   480 GTLDKL---AKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAI----------VARRNAHSA 531
            ...::|   |..|:.:..|..|. |.:::.|:.....:.|.....:          |::|....|
Mouse   932 QLQEQLRREADALETETKLFEDL-EFQQLERESRVEEERELAGQGLLRSKAELLRSVSKRKERLA 995

  Fly   532 F------------IEESYDIPRSH-------QQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMA 577
            .            ::||..:.|..       |:....:|.|  ||...|.....|...:|..|..
Mouse   996 VLDSQAGQIRAQAVQESERLAREKNAALQLLQKEKEKLNVL--ERRYHSLTGGRPFPKTTSTLKE 1058

  Fly   578 ADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCPPV 642
            |.|    .||.|:..||  |.:|:..||.|:.       ..|:...:              .||.
Mouse  1059 AQL----LISEASEIGL--ETKALGQSPRSSE-------AGASSVLL--------------TPPA 1096

  Fly   643 NRKLKPK-----VAGGLPVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIG--PP-------S 693
            :.:|.||     ....|.||...||  .|..|..|   |.:...|:|...||.  ||       |
Mouse  1097 STQLCPKAQEYVTLEQLRVVWGTPP--MPPSPSPG---LPSWASASQDLAPITCLPPMLPSSFAS 1156

  Fly   694 VDRKCKPNAYKL--------------GNSATMSPATRRSSGAPLSMVLPHETDVH-----SPAAA 739
            :.|..|.....|              |....::.|:.|||..||......:..|:     |.||:
Mouse  1157 ITRSSKMEKLLLPAVDLEQWYQELMSGLGTGLAAASPRSSPPPLPAKASRQLQVYRSKMDSDAAS 1221

  Fly   740 NAFFHETRTLPRQQHRHHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQ 794
                    .|||.:....|:|.||.|      :|:..::.:|..:.:||....||
Mouse  1222 --------PLPRTRSGPLPSSSGSSS------SSSQLSVATLGRSPSPKSALLAQ 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535
Phldb1	XP_030099813.2	FHA_PHLB1	122..240	CDD:438765
		PHA03307	251..>646	CDD:223039	53/225 (24%)
		Smc	<810..>1039	CDD:440809	35/231 (15%)
		PH_PHLDB1_2	1531..1635	CDD:270192