Protein Alignment dos and gab3

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_002931829.2
• Gene: gab3 / 100486768
• XenbaseID: XB-GENE-948841
• Length: 582
• Species: Xenopus tropicalis
• Alignment Length: 839
• Identity: 175/839 - (20%)
• Similarity: 275/839 - (32%)
• Gaps: 311/839 - (37%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQCE-QVDCG 68
            ||||||||.|::.|..||||:|.|::|.:   |:  .||||.:.|.:|...||||:.|| |...|
 Frog    10 GWLIKSPPEKKLKRYIWRRRWFVLRRGRMSGNPD--VLEYYRNKNSKKPIRVIDLNDCEVQKYIG 72

  Fly    69 LRLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADEN 133
            :.|..::.:..::|.:||.:||:||.|.||.:|:.|||.|.|:|:.              |..|:
 Frog    73 VNLIKKEFENSFVFIVKTIQRTFYLVARTEEEMQSWVNNITQICNF--------------GQLED 123

  Fly   134 RTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNS 198
            .|....|....::|.|.:...|.|:|. .|.|..||.:|...             :.|....:.|
 Frog   124 GTDSVESLSHTNSSVQASPAVSTHTSR-ITDPSFSVDSASAD-------------ITSEENRSES 174

  Fly   199 DSVYV-------NTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAA 256
            :|:::       |.|.....:..|||..:.::                      :|.|.......
 Frog   175 ESIFIPDYLFLSNCESGKLNSARCDAWSNSEK----------------------SLEQTSTDDVF 217

  Fly   257 AEQLQQQQQQAARL-AVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPIS 320
            .:.:|.|......| .|:.|. ....|..|::.:...:..::...||  :||.|    ||.:|
 Frog   218 LDSVQSQHSHNQTLFGVNPNH-NNMPPASLIMVKDLDSNGSSSDFSS--SSPLL----GPSVP-- 273

  Fly   321 ECFSGSPRFL-PGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKI-TN 383
            :.||.....: .|..||   :..|..|..|.:     |.:......:|| ||.|...:...: ..
 Frog   274 QTFSVDYTIISDGEVLP---ITPPPRPPKPNH-----FSEGRPEVISIG-NLQNGHFFPGMVPRR 329

  Fly   384 LSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFS 448
            :||..|  :|....|.:.:..|:.|.|...:..||                           ||:
 Frog   330 ISLSSL--DNVRNWRGELEDWSLRTRDKRLSLNLP---------------------------RFA 365

  Fly   449 KMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRD---LP 510
            .:                                          .:|..:..|:..:|.:   .|
 Frog   366 PL------------------------------------------YSLTSESSEDSYVPMNPNASP 388

  Fly   511 QLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNL 575
            ..|:::.::...:......:||                         |..||.||.
 Frog   389 PASESDCSTDGYIPMSPVTAAF-------------------------PFQSPVNSK--------- 419

  Fly   576 MAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCP 640
                                      .|||     ||.      .||.:|.             |
 Frog   420 --------------------------VSSP-----LPE------LPTDLEP-------------P 434

  Fly   641 PVNRKLKPKVAGGLPVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKL 705
            ||||.|||:                                              ||.:|....|
 Frog   435 PVNRDLKPR----------------------------------------------RKMRPPPLDL 453

  Fly   706 GNSATM---SPATRRSSGAPLSMVLPH-ETDVHSPA-----AANAF----FHETRTLPRQQHRHH 757
            .|.:|:   :|.||       ...:|: .|...||.     :|..|    |.|..|..:.:|| .
 Frog   454 RNLSTIREHAPLTR-------MWTVPYNRTSFTSPESDCINSAGIFSGSGFGEDVTYIQMEHR-Q 510

  Fly   758 PNSPGSMSVQHQRTASAAAAMMSLTAAA-APKQQAA-AQTEHKLQYFDLDVTNKPPLLN 814
            ..||.:.|....|..:.....:...:|: :|.|:.. ...|.::.|..:|......|.|
 Frog   511 GTSPVNGSFPWPRKFNLDYLALDFNSASPSPVQKKPFLSEEQRVDYVQVDEKKTQALQN 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	50/110 (45%)
gab3	XP_002931829.2	PH-like	1..125	CDD:473070	52/130 (40%)