Protein Alignment dos and gab1

DIOPT Version :10

• Sequence 1: NP_523890.2
• Gene: dos / 38321
• FlyBaseID: FBgn0016794
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_031751369.1
• Gene: gab1 / 100485031
• XenbaseID: XB-GENE-1008133
• Length: 719
• Species: Xenopus tropicalis
• Alignment Length: 963
• Identity: 208/963 - (21%)
• Similarity: 326/963 - (33%)
• Gaps: 384/963 - (39%)

  Fly     8 GWLIKSPPTKRIWRARWRRRYFTLKQGEI---PEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGL 69
            |||.||||.|::.|..|:||:|.|:.|.:   |:  .||||.:.:.:|...:|||:.|||||.||
 Frog    22 GWLRKSPPEKKLKRFAWKRRWFVLRSGRLTGDPD--VLEYYKNDHAKKPIRIIDLNLCEQVDAGL 84

  Fly    70 RLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADENR 134
            ....::.:..|:|||||..|.:||.||:|.:|..||..||.:|..:.|             ||:
 Frog    85 VFNKKEFENSYIFDIKTIDRVFYLVAESEEEMNKWVRNICDICGFNPT-------------DED- 135

  Fly   135 TQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSD 199
                                                       :.:||
 Frog   136 -------------------------------------------VVKPA----------------- 140

  Fly   200 SVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQ 264
               ||:|.||:               :|..|.|.|.|   ..|.:..|:::..:        |:.
 Frog   141 ---VNSEPSNQ---------------AALVQGPLPPP---YQLINMPLVESSNS--------QED 176

  Fly   265 QQAARLAVSANGVVRKLPEHLVL----TQQTLAE------------AAAQQH--------SSVQA 305
            .|...|.::...   |.||.|..    |:...||            ::||:|        ||:..
 Frog   177 PQDYLLLINCQS---KKPEPLRTQGDSTRTATAETDCNDNVATHKGSSAQKHAVNGYFQQSSIYD 238

  Fly   306 SPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLN 370
            ||:...:|                                      :.:|.||..|||::
 Frog   239 SPSRGGSS--------------------------------------STEPSFYSLPRSYS----- 260

  Fly   371 LTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIE 435
                |..|||.|            |...:|.|.:|                ||...:..|....:
 Frog   261 ----QDVSPKAT------------SPSAADMDGDS----------------NVFNMSGASSLETQ 293

  Fly   436 NESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILD-- 498
            ...|.|:|.             :||:..|:     ..:|....:|.|.:.:..|::    |.|
 Frog   294 LRQFSLSYD-------------IPPSSGST-----YQIPRTVHEGALGQSSAKLES----ITDVP 336

  Fly   499 -------FKENEKIPRD---LPQLSDTEN-----TSPAIVARRNAHSAF----------IEESYD 538
                   .:.:|:.|.:   ...:|:|::     ||....:|.|..|..          .::.||
 Frog   337 PPRPPKPHQSSERSPSEYGLTRTVSETDSNYCVPTSGMPASRSNTVSTLELSKYKKDTSSQDFYD 401

  Fly   539 IPR-------SHQQPYYN-------------VNQLLGERPVTSPHNSNPIAAS------------ 571
            |||       |..:.::.             .|:.|.|..|....||.|...|
 Frog   402 IPRPFTSDRSSSLEGFHGHFKNKSLLGLGSFSNEELDENYVPMNPNSPPRQHSNSCTEPVQETNY 466

  Fly   572 ---TPNLMAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDF 633
               ||.:.  |..:..  .....|..||    ..|||   :|.||    .:.|:
 Frog   467 VPMTPGMF--DFSSFG--MQVPPPAHMG----FRSSP---KTPPR----RSVPS----------- 505

  Fly   634 MEQADC--PPVNRKLKPKVAGGLPVVEDKPPEEFPAKP-PVGVDQLTNK-LGAAQLQQPIGPPSV 694
               |||  |||:|.|||...|..|.:         .:| |.|:::..:: :|....::.:.|..:
 Frog   506 ---ADCEPPPVDRNLKPDRKGQSPKI---------LRPKPHGLERTDSQTIGEFSTRRKVRPAPL 558

  Fly   695 DRKCKPNAYKLGNSATMSPATRR----SSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHR 755
            :.|..|...:|..:...||.||.    ||..|:.   |....|||.|:::.        .:....
 Frog   559 EIKPLPEWEELMQTPVRSPVTRSFTRDSSRFPMP---PRPDSVHSTASSSD--------SQDSEE 612

  Fly   756 HHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDV---TNKPPLLNRSS 817
            ::.....|:|.:......:::.....:....||      .:.:::|.|||:   .:.||   |..
 Frog   613 NYVAMNPSLSTEDPGLFGSSSLDEGHSPMIKPK------GDKQVEYLDLDLDSGKSTPP---RKK 668

  Fly   818 MSVGNLYSQGGNGASGMRFAGVEAGGARAPVPSSVVYRSVDFVKTEAFKRIRE 870
            .|||:     |:.|:                ...|.|..||..||.|.|..||
 Frog   669 KSVGS-----GSSAA----------------DEKVDYVVVDKQKTLALKSTRE 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dos	NP_523890.2	PH_Gab2_2	2..115	CDD:241535	49/109 (45%)
gab1	XP_031751369.1	PH_Gab1_Gab2	20..137	CDD:241297	52/173 (30%)