Protein Alignment KIF11 and sub

DIOPT Version :10

• Sequence 1: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 174/604 - (28%)
• Similarity: 268/604 - (44%)
• Gaps: 176/604 - (29%)

Human     2 ASQPNSSAKKKE-EKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVR-TGGLADKSS-- 62
            ||...|:|.... |.|.  ||.:|.||.    :.||...||.     :|.:|. |....|.:|
  Fly    72 ASCATSAADSSNVETGP--QVFLRLRPV----KDASKAYIVS-----EEANVLITSCKVDSTSNN 125

Human    63 ----RKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNC-TIFAYGQTGTGKTFTMEGERSPN 122
                .|.:.|..:|.::..|.|:|.:.|.|    .||...| ||..||.:|:|||:|:.|
  Fly   126 VNRMEKHFGFTSIFDSTVGQRDIYDTCVGP----KIMEEECVTIMTYGTSGSGKTYTLLG----- 181

Human   123 EEYTWEEDPLAGIIPRTLHQIF-----------------------------------EKLTD--- 149
                  :|..||||||.|..||                                   :||.|
  Fly   182 ------DDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCP 240

Human   150 ----------------------NGTEFSVK--VSLLEIYNEELFDLL--NPSSDVSERLQMFDDP 188
                                  ..|:.||.  ||.:|||||.::|||  .|..|     ::.:.|
  Fly   241 DISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQD-----KLGEVP 300

Human   189 R-------NKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTI-HM 245
            |       ||..|.||||..:.|.:.:|..::|..|..:.|.|:|.:||.|||||.||:|.| ..
  Fly   301 RKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKY 365

Human   246 KETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITA--LVERTPH 308
            ..:.|..:...|     ..||||||.:..:|....|.:||.|||.||:.|||.:.|  .|::..:
  Fly   366 NRSGITTQSSYK-----FCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKN 425

Human   309 ---VPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK-PEVNQ-- 367
               :|||:||||.:||.:|.|:.:.::|.|::|.....||.|:.|.:|..||||:.| |.:.|
  Fly   426 ADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHR 490

Human   368 -------KLTKKALIK--EYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQI-VEL 422
                   :.:|.:..:  :||:|:|                  :||.|     |.::.||: .:.
  Fly   491 VSYCGFMEFSKMSTCEGGDYTKELE------------------DENVR-----LQLEIEQLKYDH 532

Human   423 IEKIGAVEEELNR-----VTELFMDNKNEL-DQCKSDL---QNKTQELETTQKHLQETKLQLVKE 478
            :.::..:||:|.|     ..|:..:||.:. |:|:..|   |.:::.:.::|:...|.:::.:|:
  Fly   533 VLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKD 597

Human   479 EYITSALESTEEKLHDAAS 497
            |.         |:|.:.||
  Fly   598 EI---------EELKNPAS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	139/446 (31%)
		PRK12704	350..>508	CDD:237177	39/170 (23%)
		YhaN	380..>761	CDD:443752	27/128 (21%)
		Microtub_bind	916..1053	CDD:464048
sub	NP_611260.1	KISc	89..477	CDD:276812	131/421 (31%)
		GBP_C	<512..603	CDD:293879	24/122 (20%)
		coiled coil	576..586	CDD:293879	1/9 (11%)
		coiled coil	592..603	CDD:293879	3/19 (16%)