Protein Alignment KIF11 and Klp98A

DIOPT Version :10

• Sequence 1: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1100
• Identity: 288/1100 - (26%)
• Similarity: 475/1100 - (43%)
• Gaps: 267/1100 - (24%)

Human    18 NIQVVVRCRPFNLAERKASAHSIVECDPVRKEV------SVRTGGLADKSSRKTYTFDMVFGA-- 74
            :::|.||.||||..|....|..|:|.:..:..:      |:|..|   :.:...:|||..:.:
  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAG---RDNHHDFTFDYSYWSFD 64

Human    75 -----STKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAG 134
                 ...|..||..:...::|....|||..:|||||||:||||||.|  :||.         .|
  Fly    65 AEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNN---------PG 118

Human   135 IIPRTLHQIFEKL---TDNGTEFSVKVSLLEIYNEELFDLLNPSSD-----VSERLQMFDDPRNK 191
            :|||...::|.::   .::||.:....|.||||||.:.|||...|.     |.|...:
  Fly   119 LIPRICEELFARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSL------- 176

Human   192 RGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVT----IHMKETTIDG 252
             |..::.|.:..|.:.||:.:.:.:|.|:||||:|.||..|||||::|::|    :.|.:...:
  Fly   177 -GPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSE- 239

Human   253 EELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTP---------- 307
                .:.|::||||||||....:||..:|.:|..:||:||:|||.||:||.|:|.
  Fly   240 ----TVSKIHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSAL 300

Human   308 ------------HVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL 360
                        ::|||:|.||.:|:|||||.::|.:||.:|||..|..||||||.||:|||||:
  Fly   301 ATTPNGASKRVLYIPYRDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNII 365

Human   361 NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEK 425
            |||.||:. |...||:|..|||.:||..||     ..::..:.:.:|:: .|..:|.|     ||
  Fly   366 NKPTVNED-TNVKLIRELREEINKLKSMLA-----GDIHSLQPSLKVLA-DLQKKEAQ-----EK 418

Human   426 IGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEE 490
            :         :||.:                 |::.:..|..|||.|...:::..:...|:|  |
  Fly   419 V---------LTEEW-----------------TEKWKVAQSILQEQKSLGLRKSGVGVVLDS--E 455

Human   491 KLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAE-AQDIFGKNLNSLFNNMEELIKDGSS 554
            ..|     |:....:.|..|: |:|..:.:..:...:|: ||||             ||..||..
  Fly   456 MPH-----LIGIHNDVTTGVT-LYSLKEGETRIGSEDADVAQDI-------------ELAGDGIR 501

Human   555 KQKAMLEVHKTLFGNLLSSSVSALDTITTVAL---GSLTSIPENVS---------THVSQIFNMI 607
            .|      |.::|   |...|..|........   ..|...|:.:|         |::.:..|
  Fly   502 AQ------HCSIF---LKGGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNN-- 555

Human   608 LKEQSLAAESKTVLQEL----INVLKTDLL-SSLEMILSPTVVSILKINSQLK-----HIFKTSL 662
                  .||:..:.::|    :::.:..|: ||.|.:|:.::.|.....|..|     :..:..:
  Fly   556 ------PAEAAKLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPM 614

Human   663 TVAD-KIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQ---------- 716
            :..| :::|:.:::   |..:.|.|.:|....:....:.:.:...|||:|..::|
  Fly   615 SRDDPELQDENRKI---LDTIENALKQLNVERVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLN 676

Human   717 THSQELC--KLMNLWTERFCALEEKCENIQ-----KPLSSVQENIQQKSKDIVNKMTFHSQKF-- 772
            ...|||.  |.|.||       |:..|.:|     :.:|:.|..:..|.:|....:....|:.
  Fly   677 CREQELIARKDMLLW-------EKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQD 734

Human   773 CADSDGFSQELRNFNQEGTKLVEE-SVKHSDKL---------------NGNLEKISQETEQRCES 821
            |...|....::    :|||.|.:| .::.||.|               |..:.|:.::..::...
  Fly   735 CGKLDEMGMKI----EEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAEKERI 795

Human   822 LNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTI 886
            ||..|..     ::.::|      .:||:.:| .|....:..|.....:|...|:.|:.|..
  Fly   796 LNASTTK-----IAKVDE------TMLEIQAQ-LERLRLERAESEAESQAMRAKKQNMKLQL--- 845

Human   887 DEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQL 951
             .:|.::.:...||...:.        :.|......|..|.|....|..|..: ||.::..|.
  Fly   846 -GNKSMSTSTSTNEADDVS--------KSDTYETCDTFHTAQSNLSLVSSPTI-TEGQQSPLS-- 898

Human   952 KRKQPELLMMLNCS---ENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGG 1008
                       |||   |:..|:|..| |:..:  .:.|....:..||..:|.....|||
  Fly   899 -----------NCSCDAEDEAEDTRKD-DLSGS--SEETSRTCTAGPSSGSGSGSVGIGG 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	145/396 (37%)
		PRK12704	350..>508	CDD:237177	43/157 (27%)
		YhaN	380..>761	CDD:443752	85/421 (20%)
		Microtub_bind	916..1053	CDD:464048	23/95 (24%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	143/394 (36%)
		Kinesin_assoc	370..478	CDD:465047	36/153 (24%)
		FHA_KIF16	449..556	CDD:438760	29/144 (20%)
		SMC_N	624..>864	CDD:481474	52/277 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784