Protein Alignment KIF11 and Klp68D

DIOPT Version :10

• Sequence 1: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 217/578 - (37%)
• Similarity: 316/578 - (54%)
• Gaps: 71/578 - (12%)

Human    19 IQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYR 83
            :||||||||.:..||...:..:|...|.|..|.::.....:|..||.:|:|..:.||..|..:|.
  Fly    20 VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYH 84

Human    84 SVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLT 148
            .||.|::..|:.|:|..|||||||||||||||||.|.        .|.|.||||||..||:  |.
  Fly    85 EVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRG--------NDELMGIIPRTFEQIW--LH 139

Human   149 DNGTE---FSVKVSLLEIYNEELFDLLNPSS---DVSERLQMFDDPRNKRGVIIKGLEEITVHNK 207
            .|.||   |.|.||.||||.|||.|||.|:|   :|.||         ..||.:..|..|...:.
  Fly   140 INRTENFQFLVDVSYLEIYMEELRDLLKPNSKHLEVRER---------GSGVYVPNLHAINCKSV 195

Human   208 DEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENI 272
            :::.::::.|...||...|.||.:|||||::|.:.|.|.:|..:   .:|:|||||:||||||..
  Fly   196 EDMIKVMQVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQ 257

Human   273 GRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATIS 337
            .::||..:|.:||..||.:|.:||.||:||.|.:||||||:|||||:|||||||.::|.:||.|.
  Fly   258 SKTGASAERLKEASKINLALSSLGNVISALAESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIG 322

Human   338 PASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLA-AAREKNGVYIS 401
            |::.|..|||:||.||.|||:|.|:|..|:. .:.|.:|||.||||||||.:. ..::::...::
  Fly   323 PSNYNYNETLTTLRYASRAKSIQNQPIKNED-PQDAKLKEYQEEIERLKRLIGPQQQQRSEKQVT 386

Human   402 EENFRVMSGKL-TVQEEQIVELIEKIGAVEEELN-----RVTELFMDNKNELDQCKSDLQNKTQE 460
            .:..||...|. ||.:|....|  ::..:|:.:.     ...|...|.:||.:..||:.:.:.:.
  Fly   387 AKKQRVKKPKKETVTKEMSDSL--QVSTIEQPVEDDSDPEGAESESDKENEAEVAKSNEELERER 449

Human   461 LETTQ--KHLQETKLQLVK------EEYITSALESTEEKLHDAASK---------LLNTVEETTK 508
            :|.::  ..|.|.:.|||:      :.|....:| .|:||.:.|.:         .|...||||.
  Fly   450 VENSKLAAKLAELEGQLVRGGKNLLDTYSERQIE-LEKKLVEIAERKKREIEIQQQLELQEETTL 513

Human   509 DVS----GLHSKLDRKK-----------AVDQHNAEAQDIFGKNLNSLFNNMEELIKD 551
            ::.    .|..:::.||           |:.|...:.:....::|..|.....||:|:
  Fly   514 EIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDCKSDHNQDLRELEMAQNELVKE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	164/354 (46%)
		PRK12704	350..>508	CDD:237177	52/181 (29%)
		YhaN	380..>761	CDD:443752	49/211 (23%)
		Microtub_bind	916..1053	CDD:464048
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	163/352 (46%)
		Smc	<431..>580	CDD:440809	32/142 (23%)