Protein Alignment KIF11 and Khc

DIOPT Version :10

• Sequence 1: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 1036
• Identity: 290/1036 - (27%)
• Similarity: 479/1036 - (46%)
• Gaps: 184/1036 - (17%)

Human     8 SAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVF 72
            ||:::.....:|:||.|.||.|.:|.||.:..:|:.....:|..:...|       |.|.||.||
  Fly     2 SAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG-------KVYLFDKVF 59

Human    73 GASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP 137
            ..:..|..||......|:.:|:.|||.||||||||.:|||.||||....:.:        .||||
  Fly    60 KPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVK--------QGIIP 116

Human   138 RTLHQIFEKL--TDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE-RLQMFDDPRNKRGVIIKGL 199
            |.::.||..:  .:...||.:|||..|||.:::.|||    |||: .|.:.:|  ..|...:||.
  Fly   117 RIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLL----DVSKVNLSVHED--KNRVPYVKGA 175

Human   200 EEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLV 264
            .|..|.:.::|::::|:|.:.|..|.|.||.:||||||||  .|::|:..::.::.:. |||.||
  Fly   176 TERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVF--LINVKQENLENQKKLS-GKLYLV 237

Human   265 DLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVE-RTPHVPYRESKLTRILQDSLGGRT 328
            ||||||.:.::||......||.|||:||..||.||:||.: ...|:|||:||||||||:||||..
  Fly   238 DLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNA 302

Human   329 RTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEE----------IE 383
            ||:|:...||||.|..||.|||::..|||.:.|...||::||.:...:.|.:|          :|
  Fly   303 RTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVE 367

Human   384 RLKRDLAAAREKNGVYISEE------------NFRV---------------------MSGKLTVQ 415
            :|:.:||..|....|...|:            |..|                     ||..:.|.
  Fly   368 KLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVN 432

Human   416 EE-----QIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHL----QET 471
            |:     :...|.:::...:||:|:.::.....|.::.:.:..:.|..:|.||.|..:    ||.
  Fly   433 EQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQEN 497

Human   472 KLQLVKEEYITSALESTEEKL--HDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIF 534
              :..||| :...|::.||..  :|..|:   .::...||:..|:.:|.:|::|  .||.:.::
  Fly   498 --ESAKEE-VKEVLQALEELAVNYDQKSQ---EIDNKNKDIDALNEELQQKQSV--FNAASTEL- 553

Human   535 GKNLNSLFNNMEELIKDGSSKQKAML-EVHKTLF------GNLLSSSVSALDTITTVALGSLTSI 592
                        :.:||.||.||..: |:...|.      |..::...|::|...:...|:..|.
  Fly   554 ------------QQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASK 606

Human   593 PENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHI 657
            .|...| ::::|...:|     .|:|.:.|...| ::|....|.:           ||:...|.:
  Fly   607 VEEDFT-MARLFISKMK-----TEAKNIAQRCSN-METQQADSNK-----------KISEYEKDL 653

Human   658 FKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNL--TEDLKTIKQTHSQ 720
            .:..|.::.. |.:.|.|...:....|....|:|. |.||   :::|..|  .|.:..:.....|
  Fly   654 GEYRLLISQH-EARMKSLQESMREAENKKRTLEEQ-IDSL---REECAKLKAAEHVSAVNAEEKQ 713

Human   721 ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKS------KDIVNKMTFHSQKFCADSDGF 779
            ...:|.:::..:   ::|..|...:.:|.:::.|..|.      ||:..|:....|:..||.:
  Fly   714 RAEELRSMFDSQ---MDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYE-- 773

Human   780 SQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQEL 844
                        |:.:|..:.|.:|. |:...::..||..:.|        :....::.:..|.|
  Fly   774 ------------KVRQEDAEKSSELQ-NIILTNERREQARKDL--------KGLEDTVAKELQTL 817

Human   845 HNLLEVVSQCCE--ASSSDITEKS--DGRKAAHEKQHNIF----LDQMTIDEDKLIAQNLELNET 901
            |||.::..|..:  ...:.:.|:|  ||...| :||...|    |||:|....:|:..|.:|...
  Fly   818 HNLRKLFVQDLQQRIRKNVVNEESEEDGGSLA-QKQKISFLENNLDQLTKVHKQLVRDNADLRCE 881

Human   902 IKIGLTKLNCFLEQDLKL-----DIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPE 957
            :.....:|.|.:|:...|     :...|....||.|.|....::...|:   ..|.|:.|:
  Fly   882 LPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQ---KHLGRRGPQ 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	149/355 (42%)
		PRK12704	350..>508	CDD:237177	44/211 (21%)
		YhaN	380..>761	CDD:443752	89/449 (20%)
		Microtub_bind	916..1053	CDD:464048	10/47 (21%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	146/346 (42%)
		Smc	<341..>807	CDD:440809	105/535 (20%)
		Khc_CBD_cc	856..925	CDD:467880	17/68 (25%)