Protein Alignment KIF11 and Klp3A

DIOPT Version :10

• Sequence 1: NP_004514.2
• Gene: KIF11 / 3832
• HGNCID: 6388
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Alignment Length: 1132
• Identity: 289/1132 - (25%)
• Similarity: 495/1132 - (43%)
• Gaps: 246/1132 - (21%)

Human    19 IQVVVRCRPFNLAERKASAHSIVE--CDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDV 81
            :.|.:|.||...:|........||  .|.. .:|:|        :..::||::.||.....|.|:
  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGA-PQVTV--------NRNESYTYNYVFDIDDSQKDL 64

Human    82 YRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEK 146
            :.:.|...:.:::.|||.||.||||||:|||:||      ...:....|...|:|||.:|.||..
  Fly    65 FETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM------GTAFNGVLDDHVGVIPRAVHDIFTA 123

Human   147 LTDNGTE--FSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDE 209
            :.:..:|  |:|..|.:|:|.|:.:||.  ||...::..: |....|..:|:.||.|:.|.:..:
  Fly   124 IAEMQSEFRFAVTCSFVELYQEQFYDLF--SSKTRDKATV-DIREVKNRIIMPGLTELVVTSAQQ 185

Human   210 VYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGR 274
            |...|.:|:|.|..|||.||..|||||::|::|  :..|.:||::.|...:.|||||||||...:
  Fly   186 VTDHLIRGSAGRAVAATAMNETSSRSHAIFTLT--LVATKLDGKQSVTTSRFNLVDLAGSERCSK 248

Human   275 SGAVDKRAREAGNINQSLLTLGRVITAL--VERTPHVPYRESKLTRILQDSLGGRTRTSIIATIS 337
            :.|...|.:|..|||:.||.||.||.||  .:...::|||:|||||:|||||||.:.|.:||.:|
  Fly   249 TLASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVS 313

Human   338 PASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISE 402
            ||..|:.||||||.||.||..|.|||.||        :..:..|:..||..:...|.:
  Fly   314 PADYNVAETLSTLRYADRALQIKNKPVVN--------LDPHAAEVNMLKDVIQKLRVE------- 363

Human   403 ENFRVMSGKLTVQEEQIVELIEKIGAV-------EEELNRVTELFMDNKNELDQCKSD---LQNK 457
               .:..||::      ..||..:||.       ||.|..    .|.|..|:.:.|..   ||::
  Fly   364 ---LLSGGKMS------SSLISAVGAAGLGAIPCEESLAG----SMANAAEIQRLKEQVRTLQDR 415

Human   458 TQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEET------TKDVSGLHSK 516
            .::|   |:.|.::.|.|.::|......|...:||....|:|.|.:::.      .::.:|.:..
  Fly   416 NRKL---QQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEM 477

Human   517 LDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDG-SSKQKAMLEVHKTLFGNLLSSSVSALDT 580
            .|....|::.:.|.|           ...|||...| .|:|:.....|       .....|..|
  Fly   478 RDFSLLVNRVHVELQ-----------RTQEELESQGHESRQRLSSRSH-------TEGGESGGD- 523

Human   581 ITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDL----------LSS 635
                      .:.|.:.:|..:..|   |:.:.|.|.:.:.::|  .||.:|          |.|
  Fly   524 ----------EVHEMLHSHSEEYTN---KQMNFAGELRNINRQL--DLKQELHERIMRNFSRLDS 573

Human   636 ----LEMILSPTVVSILK-----INSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHEL-- 689
                :::.|....:..|:     :..||::|  .|..::.|:.:::::.   |.:|...:.:|
  Fly   574 DDEDVKLRLCNQKIDDLEAERRDLMDQLRNI--KSKDISAKLAEERRKR---LQLLEQEISDLRR 633

Human   690 ----QENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSV 750
                |.|.:....:.:::..||:.:::|:|:: ..:|.:.|...:|:|         .|..:...
  Fly   634 KLITQANLLKIRDKEREKIQNLSTEIRTMKES-KVKLIRAMRGESEKF---------RQWKMVRE 688

Human   751 QENIQQKSKD------IVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLE 809
            :|..|.||||      ||.:.|.||::        .|.|:       :..||::..:.:|...||
  Fly   689 KELTQLKSKDRKMQSEIVRQQTLHSKQ--------RQVLK-------RKCEEALAANKRLKDALE 738

Human   810 KISQETEQR------------CESLNTRTVYFSEQWVS-------SLNEREQELHNLLE---VVS 852
            :.:....||            ..:.|.:|    :.||.       ||.:.|..|..|:|   |::
  Fly   739 RQASAQAQRHKYKDNGGSAAGSSNANAKT----DSWVDRELEIILSLIDAEHSLEQLMEDRAVIN 799

Human   853 QCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDL 917
            ........:.|  ||..:||.:.:....|      |::|..:|.::::     |.:..|..:.|.
  Fly   800 NHYHLLQQEKT--SDPAEAAEQARILASL------EEELEMRNAQISD-----LQQKVCPTDLDS 851

Human   918 KL-DIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPD------ 975
            :: .:..|.....:|......|::|      |.|.:|        |..|..|::.|..|
  Fly   852 RIRSLAEGVQSLGESRTVSKQLLKT------LVQQRR--------LQASSLNEQRTTLDELRAQL 902

Human   976 VDVEE----------AVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTL 1030
            :|.::          .:..|:.|:.|:|:.:.:..|..........:...:|..:|::...|  |
  Fly   903 LDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTANQRWAEARSPAEDQQRNQI--L 965

Human  1031 E-----RSKVEETTEHLVTKSRLPLRA 1052
            |     |..:::..:.|..|::...:|
  Fly   966 EELLSSREALQQELDKLRAKNKSKSKA 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	141/354 (40%)
		PRK12704	350..>508	CDD:237177	42/173 (24%)
		YhaN	380..>761	CDD:443752	84/428 (20%)
		Microtub_bind	916..1053	CDD:464048	28/159 (18%)
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	135/346 (39%)
		Smc	<453..>985	CDD:440809	117/628 (19%)
		Metallothio	<1071..1115	CDD:395080