DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF11 and cut7

DIOPT Version :9

Sequence 1:	NP_004514.2	Gene:	KIF11 / 3832	HGNCID:	6388	Length:	1056	Species:	Homo sapiens
Sequence 2:	NP_594527.1	Gene:	cut7 / 2542732	PomBaseID:	SPAC25G10.07c	Length:	1085	Species:	Schizosaccharomyces pombe

Alignment Length:	1080	Identity:	344/1080 - (31%)
Similarity:	542/1080 - (50%)	Gaps:	181/1080 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    13 EEKGKNIQVVVRCRPFNLAE-RKASAHSIVECDPVRKEVSVRTGGLADKSS---RKTYTFDMVFG 73
            :|...||.||||.|.....| |..|:.::.....:..|::::    :|.||   .|||.||.|||
pombe    67 DENETNINVVVRVRGRTDQEVRDNSSLAVSTSGAMGAELAIQ----SDPSSMLVTKTYAFDKVFG 127

Human    74 ASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPR 138
            ....|:.::.:.|.|:|::|:.|||||||||||||||||:||.|:.|.::....|.   ||:|||
pombe   128 PEADQLMLFENSVAPMLEQVLNGYNCTIFAYGQTGTGKTYTMSGDLSDSDGILSEG---AGLIPR 189

Human   139 TLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERL----QMFDDPRNKRGVIIKGL 199
            .|:|:|..|.::..|::||.|..|:||||:.|||     |||.|    ::|:|...:..|:|.|:
pombe   190 ALYQLFSSLDNSNQEYAVKCSYYELYNEEIRDLL-----VSEELRKPARVFEDTSRRGNVVITGI 249

Human   200 EEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMK-------ET---TI--DG 252
            ||..:.|..:..::|.:|:.:|..|||..|..||||||:|::|:|.|       ||   ||  :.
pombe   250 EESYIKNAGDGLRLLREGSHRRQVAATKCNDLSSRSHSIFTITLHRKVSSGMTDETNSLTINNNS 314

Human   253 EELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLT 317
            ::|::..||::||||||||||||||.:|||||.|.||||||||||||.||||:..|:||||||||
pombe   315 DDLLRASKLHMVDLAGSENIGRSGAENKRARETGMINQSLLTLGRVINALVEKAHHIPYRESKLT 379

Human   318 RILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEI 382
            |:|||||||:|:||:|.|:|..:.|||||:||||||.|||:|.|||:.||.:.:|.|||:...:|
pombe   380 RLLQDSLGGKTKTSMIVTVSSTNTNLEETISTLEYAARAKSIRNKPQNNQLVFRKVLIKDLVLDI 444

Human   383 ERLKRDLAAAREKNGVYISEENF-----RVMSGKLTVQEE----QIVELIEKIGAVEEELNRVTE 438
            ||||.||.|.|:|||||::|..:     ||.:..|..||:    ::::|  .:.:..|:|..|::
pombe   445 ERLKNDLNATRKKNGVYLAESTYKELMDRVQNKDLLCQEQARKLEVLDL--NVKSSREQLQYVSK 507

Human   439 LFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTV 503
            ...::|.|::..:..|.|.:.|||:.:...::.|.:||.|.......|:.|.|:...|:.|....
pombe   508 SNQEHKKEVEALQLQLVNSSTELESVKSENEKLKNELVLEIEKRKKYETNEAKITTVATDLSQYY 572

Human   504 EETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGK---NLNSLFNNMEELIKDGSSKQKAMLEVHKT 565
            .|:.:.::.|:.||||   .:::|.|.::.|..   ||.::..:......|.::.       :.|
pombe   573 RESKEYIASLYEKLDR---TERNNKENENNFWNLKFNLLTMLRSFHGSFTDETNG-------YFT 627

Human   566 LFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVL-- 628
            |..:..:|....|:|.:...|.|:|.|.|    |...:...:...:|..|...:.|..:::.|
pombe   628 LLNDFNASMEELLNTHSNQLLISMTKITE----HFQSLDEALQSARSSCAVPNSSLDLIVSELKD 688

Human   629 -KTDLLSSLEMILSPTVVSILKINS------------------QLKHIFKTSLTVADKIEDQKKE 674
             |..||.:||..|....:|..|:.:                  ||....::...:....|:.:||
pombe   689 SKNSLLDALEHSLQDISMSSQKLGNGISSELIELQKDMKESYRQLVQELRSLYNLQHTHEESQKE 753

Human   675 LDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCK-----LMNLWTERFC 734
            |   :..:.|::..|.:....||.::.....:...|.|:..::..|:|..     :.|...|:..
pombe   754 L---MYGVRNDIDALVKTCTTSLNDADIILSDYISDQKSKFESKQQDLIANIGKIVSNFLQEQNE 815

Human   735 ALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVK 799
            :|..|.:.:...|:....|| :|:.:|:|.   .|::|          |||           :..
pombe   816 SLYTKADILHSHLNDTNSNI-RKANEIMNN---RSEEF----------LRN-----------AAS 855

Human   800 HSDKLNGNLEKISQETEQRCESL---------NTRTVY-----FSEQWVSSLNEREQELHNLLEV 850
            .::.:..|.|:|.:..|...:.|         |:|::|     .:|.....:|...|.|..||:.
pombe   856 QAEIVGANKERIQKTVENGSQLLDSKSKAIHSNSRSMYDHCLALAESQKQGVNLEVQTLDRLLQK 920

Human   851 VSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQ 915
            |.:..|          |..|..|::    .||.:    :.|:..|..|.::||...|:|....:.
pombe   921 VKEHSE----------DNTKEKHQQ----LLDLL----ESLVGNNDNLIDSIKTPHTELQKITDH 967

Human   916 DLKLDIPTGTTP-----------------QRKSYLYPSTLVRTE-----PREHLLDQLKRKQPEL 958
            .||     |||.                 ..::.:..::||:.|     |.       ||:.|..
pombe   968 VLK-----GTTSLANHTNELLGLGDESLCNLETTIEDTSLVKLETTGDTPS-------KRELPAT 1020

Human   959 LMMLNCSENNKEETIPDVDVEEAVLGQ-YTEEPLSQEPSV 997
            ......|...||.|..::|.::..:.: ||....:.||.|
pombe  1021 PSWTRDSSLIKETTNLNLDSDKKFVRETYTSSNQTNEPDV 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	184/371 (50%)
		KISc	18..366	CDD:214526	183/367 (50%)
		Microtub_bind	916..1053	CDD:290642	22/105 (21%)
cut7	NP_594527.1	KISc_BimC_Eg5	70..429	CDD:276815	183/370 (49%)
		KISc	72..428	CDD:214526	183/367 (50%)
		SbcC	<398..>966	CDD:223496	157/629 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	305	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	416	1.000	Inparanoid score	I412
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto146163
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850