DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF11 and Kif11

DIOPT Version :9

Sequence 1:	NP_004514.2	Gene:	KIF11 / 3832	HGNCID:	6388	Length:	1056	Species:	Homo sapiens
Sequence 2:	NP_001162583.1	Gene:	Kif11 / 171304	RGDID:	621258	Length:	1056	Species:	Rattus norvegicus

Alignment Length:	1056	Identity:	848/1056 - (80%)
Similarity:	952/1056 - (90%)	Gaps:	1/1056 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKT 65
            |||||:||:||||||||||||||||||||||||||:|||:||||..||||||||.||.||:||||
  Rat     1 MASQPSSSSKKKEEKGKNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSRKT 65

Human    66 YTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEED 130
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat    66 YTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEED 130

Human   131 PLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVI 195
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
  Rat   131 PLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVI 195

Human   196 IKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 IKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGK 260

Human   261 LNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLG 325
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
  Rat   261 LNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLG 325

Human   326 GRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLA 390
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat   326 GRTRTSIIATISPASLNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLA 390

Human   391 AAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQ 455
            |||||||||||||:||.|:||:|||||||.||.||||.:||||::..|||.|::.||:|||||||
  Rat   391 AAREKNGVYISEESFRAMNGKVTVQEEQIAELAEKIGVLEEELSKAAELFTDSEKELNQCKSDLQ 455

Human   456 NKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRK 520
            .||||||||||||||||||||||||::||||.||:|||:.||||||||:|||:||||||||||||
  Rat   456 TKTQELETTQKHLQETKLQLVKEEYVSSALERTEKKLHETASKLLNTVKETTRDVSGLHSKLDRK 520

Human   521 KAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVA 585
            :|:|.||||||:.||::|:||||||||||:|||.||||||:|||.|||||:||||||||||:|.|
  Rat   521 RAIDAHNAEAQESFGRSLSSLFNNMEELIRDGSEKQKAMLDVHKALFGNLMSSSVSALDTISTTA 585

Human   586 LGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKI 650
            |.||.||||||...||||.:|||:||||||:||||||..|:.|.|:|.:||:.|::|.|||||.|
  Rat   586 LESLMSIPENVLARVSQISDMILEEQSLAAQSKTVLQGSIDELVTNLFTSLKTIIAPGVVSILNI 650

Human   651 NSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIK 715
            |.||:|||:.|:|:|:|:||||:|:|.||||||||||||:|||:.|||||||.||||||||||||
  Rat   651 NRQLQHIFRASVTMAEKVEDQKREIDSFLSILCNNLHELRENTVSSLVESQKLCGNLTEDLKTIK 715

Human   716 QTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS 780
            :|||||||:|.:.|.|||||||:|..||||||:|:|||.::||.||:||.|.||:|..|||||..
  Rat   716 ETHSQELCQLSSSWAERFCALEKKYANIQKPLNSIQENTERKSTDIINKTTVHSKKILADSDGLL 780

Human   781 QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELH 845
            ||||:||:|||:|||:||.|...|:.|||.:|||..|||.:|||.||:||:||.|.|::|::||.
  Rat   781 QELRHFNEEGTQLVEDSVGHCGSLSSNLETVSQEITQRCGTLNTSTVHFSDQWASCLSKRKEELQ 845

Human   846 NLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLN 910
            ||:|.|:.|||||||:||||..|.:||.|.||:.|:.|:|.||:|..|.:|||::|||.||||||
  Rat   846 NLMEFVNGCCEASSSEITEKIRGHRAAIESQHSSFVVQITSDEEKFKAGSLELDKTIKTGLTKLN 910

Human   911 CFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPD 975
            |||:||||||||||.||:||:||||||||||||||.|||||::|||:.||||||||::| ||..|
  Rat   911 CFLQQDLKLDIPTGMTPERKNYLYPSTLVRTEPREQLLDQLQKKQPKPLMMLNCSESSK-ETSQD 974

Human   976 VDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTE 1040
            ::.:..||.|.|||.:||||.|....||||.||||||||||.|||||||||:|.:|:.||||.:|
  Rat   975 MEEDREVLEQSTEELVSQEPCVHTSADCSSSGGVPFFQHKKPHGKDKENRGLNPVEKGKVEEASE 1039

Human  1041 HLVTKSRLPLRAQINL 1056
            |.::||||||||.|||
  Rat  1040 HSISKSRLPLRASINL 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	340/351 (97%)
		KISc	18..366	CDD:214526	336/347 (97%)
		Microtub_bind	916..1053	CDD:290642	96/136 (71%)
Kif11	NP_001162583.1	KISc_BimC_Eg5	16..368	CDD:276815	340/351 (97%)
		KISc	18..366	CDD:214526	336/347 (97%)
		DUF4795	416..>486	CDD:292662	53/69 (77%)
		Microtub_bind	916..1052	CDD:290642	96/136 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83691814
Domainoid	1	1.000	795	1.000	Domainoid score	I2704
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3322
Inparanoid	1	1.050	1672	1.000	Inparanoid score	I2208
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37911
OrthoDB	1	1.010	-	-		D111985at33208
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto130030
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410