DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16758 and PNP

DIOPT Version :9

Sequence 1:	NP_001261330.1	Gene:	CG16758 / 38315	FlyBaseID:	FBgn0035348	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_000261.2	Gene:	PNP / 4860	HGNCID:	7892	Length:	289	Species:	Homo sapiens

Alignment Length:	285	Identity:	145/285 - (50%)
Similarity:	195/285 - (68%)	Gaps:	2/285 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 EDTYPYEVIEEIADFITKGSGMRPKIGIICGSGLGSLADMIQDPKIFEYEKIPNFPVSTVEGHAG 173
            |:.|.||..:..|:::...:..||::.||||||||.|.|.:...:||:|.:|||||.|||.||||
Human     2 ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAG 66

  Fly   174 RLVVGTLEGATVMAMQGRFHFYEGYPLAKCSMPVRVMKLCGVEYLFATNAAGGINPRFAVGDIML 238
            |||.|.|.|...:.||||||.||||||.|.:.||||..|.||:.|..||||||:||:|.||||||
Human    67 RLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIML 131

  Fly   239 MHDHVNMLGFAGNSPLQGPNDPRFGPRFPALVNSYNKDLINKAIEIAKAMGIESNIHVGVYSCLG 303
            :.||:|:.||:|.:||:||||.|||.||||:.::|::.:..:|:...|.||.:..:..|.|..:.
Human   132 IRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVA 196

  Fly   304 GPNYETIAELKALRMMGVDAVGMSTVHEVITARHCDMKVFAFSLITNKCATEYSDKKDDEANHDE 368
            ||::||:||.:.|:.:|.||||||||.|||.||||.::||.|||||||...:|...  ::|||:|
Human   197 GPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESL--EKANHEE 259

  Fly   369 VMAVAKNRQKACCELVSRLIREIHL 393
            |:|..|...:...:.||.|:..|.|
Human   260 VLAAGKQAAQKLEQFVSILMASIPL 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16758	NP_001261330.1	PRK08202	113..391	CDD:236183	141/277 (51%)
CG16758	NP_001261330.1	XapA	116..391	CDD:223084	139/274 (51%)
PNP	NP_000261.2	PNPH	26..280	CDD:273764	136/255 (53%)
PNP	NP_000261.2	Phosphate binding. /evidence=ECO:0000269\|PubMed:23438750, ECO:0000305\|PubMed:14706628, ECO:0000305\|PubMed:1763067, ECO:0007744\|PDB:1RCT, ECO:0007744\|PDB:1ULA, ECO:0007744\|PDB:1ULB, ECO:0007744\|PDB:1V3Q, ECO:0007744\|PDB:4EAR, ECO:0007744\|PDB:4EB8, ECO:0007744\|PDB:4GKA	84..86		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147141
Domainoid	1	1.000	280	1.000	Domainoid score	I1693
eggNOG	1	0.900	-	-		E1_COG0005
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H227
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2739
Isobase	1	0.950	-	0	Normalized mean entropy	S669
OMA	1	1.010	-	-		QHG58962
OrthoDB	1	1.010	-	-		D1078969at2759
OrthoFinder	1	1.000	-	-		FOG0001804
OrthoInspector	1	1.000	-	-		oto89927
orthoMCL	1	0.900	-	-		OOG6_101826
Panther	1	1.100	-	-	O	PTHR11904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2236
SonicParanoid	1	1.000	-	-		X1164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750