DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d20 and ERG5

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_013728.1	Gene:	ERG5 / 855029	SGDID:	S000004617	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	544	Identity:	118/544 - (21%)
Similarity:	202/544 - (37%)	Gaps:	136/544 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGP--ISIPILGCGLQALHLGAENIIGWVGEKF 64
            :|.:....:.:||.||     |.....:|.:|.||  ...||:|..|::|           ..||
Yeast    45 YLKIFATLICILLVWD-----QVAYQIKKGSIAGPKFKFWPIIGPFLESL-----------DPKF 93

  Fly    65 DKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEK-GQLYEYLRPFLND---------GLLVS 119
            ::|...:....|....|:.|    |..|.|:..|..| .|..::::|.:.|         ..:..
Yeast    94 EEYKAKWASGPLSCVSIFHK----FVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFL 154

  Fly   120 TGRKWHARRKIFTHAFHFKVLEHYV----EIMDRHSSVMV------------------------- 155
            .|:.....||.....|..:.|..|:    :|||::....|
Yeast   155 DGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALS 219

  Fly   156 -----------DNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSVV 209
                       |.:||:||.       .|:..|||:::               :||.|     :.
Yeast   220 LNSFCGNYITEDQVRKIADD-------YYLVTAALELV---------------NFPII-----IP 257

  Fly   210 YIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSL 274
            |.:           .|.....|               |...|:.....:..:...|.|. :|:.:
Yeast   258 YTK-----------TWYGKKTA---------------DMAMKIFENCAQMAKDHIAAGG-KPVCV 295

  Fly   275 GDA--EIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPE 337
            .||  ::...::.:..|   .|.|.::..::.:|.|.|.||:|...|.:||........:|..|:
Yeast   296 MDAWCKLMHDAKNSNDD---DSRIYHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPD 357

  Fly   338 VQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIG-DKTI 401
            |..:|.||...|...|.|..:....::.:||.:.|||||:|..|||..:....:|...:. :.|.
Yeast   358 VLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYTA 422

  Fly   402 PANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMK 466
            |....:...||.|..|...:.:|..|.|||::|..:.......::.|..||..|:||.:.::...
Yeast   423 PKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFA 487

  Fly   467 VLISKVLRF----YELLPLGEELK 486
            .|:.|...:    :.:.||.|::|
Yeast   488 ALLGKFALYTDFHHTVTPLSEKIK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	110/512 (21%)
ERG5	NP_013728.1	CYP61_CYP710	103..522	CDD:410703	100/470 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I1557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	4	3.960