DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	469	Identity:	152/469 - (32%)
Similarity:	239/469 - (50%)	Gaps:	64/469 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YGKTFRFWILGE-----SLIYTKDLQYFETILSSTTLLEKGQ-LYEYLRPFLNDGLLVSTGRKWH 125
            |.:.|:.| :|.     ||.:...::  ..|.:|..:..|.: .|.:|.|:|.||||:|.|.||.
Human    84 YPQGFKVW-MGPISPLLSLCHPDIIR--SVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWS 145

  Fly   126 ARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVA-DGKTAVDMLKYVSLAALDVITEAAMGV 189
            ..|::.|.||||.:|:.|::|.:...::|....:.:| :|...:||.:::||..||.:.:.....
Human   146 RHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSF 210

  Fly   190 QVNAQNDPDFPYIKA---LKSVV---------------YIQPDRMFRFSRRYNWLFPLAAPLLHR 236
            ..:.|..|. .||.|   |.::|               |:.||.. ||.|.
Human   211 DSHCQEKPS-EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQ-RFRRA-------------- 259

  Fly   237 QLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----ILLQSSIN 297
                 .|::|||||.||.|||.|:          |....|..:.:|::...||    :||....:
Human   260 -----CRLVHDFTDAVIQERRRTL----------PSQGVDDFLQAKAKSKTLDFIDVLLLSKDED 309

  Fly   298 NQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ 362
            .:.|||.|||.|.|||||||.|||:||:|..||.:|:|||.|:|..:|:|.:|.......:....
Human   310 GKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDD 374

  Fly   363 LQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLS 426
            |..|.:|...:||::||:||||.|.||..:::.:.| :.||......:.::..|.:...:|||..
Human   375 LAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEV 439

  Fly   427 FRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNF 491
            :.|.||..:..:..:..|::||||||:|||||.||:.||||:::..|..:.:||...|.:.....
Human   440 YDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPEL 504

  Fly   492 ILRSASGINVGLRP 505
            :||:..|:.:.:.|
Human   505 VLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	148/455 (33%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	151/464 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750