DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	512	Identity:	163/512 - (31%)
Similarity:	271/512 - (52%)	Gaps:	48/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFD----KYGK 69
            ||:|:.......:|||:|. :.|..|||.:..:||   ....|..:|:     |..|    |:..
Mouse    23 ALVLMQAMKLYLRRQRLLR-DLSPFPGPPAHWLLG---HQKFLQEDNM-----ETLDEIVKKHPC 78

  Fly    70 TFRFWILG--ESLIYTKDLQYFETILSSTTLLEKGQ-LYEYLRPFLNDGLLVSTGRKWHARRKIF 131
            .|..|: |  ::..|..|..|.:..||.|.  .|.| |::.|.|.:..|||...|.:|...|.:.
Mouse    79 AFPCWV-GPFQAFFYIYDPDYAKIFLSRTD--PKMQYLHQLLTPCIGRGLLNLDGPRWFQHRCLL 140

  Fly   132 THAFHFKVLEHYVEIMDRHSSVMVDNLRKV-ADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQ- 194
            |.|||..:|:..|:.|.....||:|...|: ...:|.:::.::::|..||:|.:.|.|.:.|.|
Mouse   141 TPAFHQDILKPCVDTMAHSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQI 205

  Fly   195 NDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLH-RQLLSDIRVMHDFTDKVISERRE 258
            |.....|:||...:..|...|::.|...::.:|.| :|..| .|.|.  :|:|.:|:|:|.:|::
Mouse   206 NGTYESYVKATFELGEIISSRLYNFWHHHDIIFKL-SPKGHCFQELG--KVIHQYTEKIIQDRKK 267

  Fly   259 TVR-RAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQ-PLSDADIREEVDTFMFEGDDTT 321
            .:: :.|.|.|             ::....|||:|.:...:: ..||||:|.||:|||:.|.|.:
Mouse   268 ILKNQVKQDDT-------------QTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDAS 319

  Fly   322 SSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAI 386
            ::.:|..||.:|.:||.|.|...|::.:||..:|  :|..||.::.|....||||:||.||||:|
Mouse   320 AASISWLLYCLALNPEHQDRCRTEIRSILGDGSS--ITWEQLDEMSYTTMCIKETLRLIPPVPSI 382

  Fly   387 GRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSA 450
            .|...|.|.:.| .::||..::.|.::..|.:...:.||..|.|.||.::.....:..|::|||:
Mouse   383 SRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRFTKENSDQRHPCAFLPFSS 447

  Fly   451 GPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKP---MLNFILRSASGINVGLR 504
            ||:|||||:||:||:||.|:.:|..:::.|  :..:|   ..:.:||...||.:.|:
Mouse   448 GPRNCIGQQFAMLELKVAIALILLHFQVAP--DLTRPPAFSSHTVLRPKHGIYLHLK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	150/474 (32%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	154/482 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850