DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	531	Identity:	161/531 - (30%)
Similarity:	267/531 - (50%)	Gaps:	58/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLTLITG------ALILLLTWDFGRKRQRVLAF----EKSAIPGPISIPILGCGLQALHLGAENI 56
            |..|:.|      |.||..|:.|.....|:..|    :|:...|.:.:      :|:...|.:.:
Mouse    19 WHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGM------IQSNEEGMQLV 77

  Fly    57 IGWVGEKFDKYGKTFR----FWILGE--SLIYTKDLQYFETILSSTTLLEKGQL--YEYLRPFLN 113
                    .:.|:||:    || ||.  .::...|..:...:|.:..|:....:  ..:|:|:|.
Mouse    78 --------TEMGQTFQDVHLFW-LGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLG 133

  Fly   114 DGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKV-ADGKTAVDMLKYVSLA 177
            |||.:|:|.||...|::.|.||||.:|:.||:|.::..::|....:.: ::|...::|.:::||.
Mouse   134 DGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLM 198

  Fly   178 ALDVITEAAMGVQVNAQNDPDFPYIKA---LKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLL 239
            .||.:.:...|...|.|..|. .||.|   |.|::..:..::|.|   .::|:...|.  .|:..
Mouse   199 TLDSLQKCLFGFDSNCQESPS-EYISAILELSSLIIKRSLQLFLF---VDFLYYHTAD--GRRFR 257

  Fly   240 SDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----ILLQSSINNQP 300
            ....::|:|||.||.|||.|:.....|...:          ||::...||    :||....:.:.
Mouse   258 KACDLVHNFTDAVIRERRHTLSSQNHDEFLK----------SKTKSKTLDFIDVLLLAKDEHGKE 312

  Fly   301 LSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQD 365
            |||.|||.|.|||||.|.|||:|.:|..||.:|||||.|:|..:|:|.:|.......:....|..
Mouse   313 LSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQ 377

  Fly   366 LKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRP 429
            |.:|...|||::||:.||..:.|...:::.:.| :.||......:.::..|.:.:.:|||..:.|
Mouse   378 LPFLTMCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYDP 442

  Fly   430 ERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILR 494
            .||..:..|..:..|::||||||:|||||.||:.||||.::..|..:.:||..:|.:.....|||
Mouse   443 FRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILR 507

  Fly   495 SASGINVGLRP 505
            :..|:.:.:.|
Mouse   508 AEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	145/475 (31%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	150/492 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740