Protein Alignment Cyp4d20 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 137/588 - (23%)
• Similarity: 235/588 - (39%)
• Gaps: 131/588 - (22%)

  Fly     9 ALILLLTW----DFGRKRQRVLAFEKSAIPGPISIPILG-----------------------CGL 46
            ||:.||.|    .|.|       .||..:..|...|.:|                       ||
Human    23 ALLALLKWYSTSAFSR-------LEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCG- 79

  Fly    47 QALHLG-----------------AENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILS 94
              .:||                 .||...:.    ::......|..:.:|:::.:|.::.|.
Human    80 --YYLGRRMFIVISEPDMIKQVLVENFSNFT----NRMASGLEFKSVADSVLFLRDKRWEEV--- 135

  Fly    95 STTLLEKGQLYEYLRP-FLND-GLLVSTGR-KWH-----ARRKI----FTHAFHFKVLEHY---- 143
                  :|.|.....| .||: |||:...| |.|     |.::|    .:......|..||
Human   136 ------RGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLP 194

  Fly   144 ---VEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKAL 205
               |.::.:...:::.:|::.|:...|.|:.:.......||:...|.|..|::...|:.|::|..
Human   195 FCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHC 259

  Fly   206 KSVVYIQPDRMFRFS----------RRYNWLFPLAAPLLHR----------QLLSDIRVMHDFTD 250
            |        |.|.|.          ...:.:.|||..|.::          :|:.::..:.|  .
Human   260 K--------RFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRD--Q 314

  Fly   251 KVISERRETVRRAKADGTY--RPLSLGDAEI--------GSKSQMALLDILLQSSINNQPLSDAD 305
            :...|||....:...|..:  .|:.:.|.:|        |.|...:...   |.|...:||:..:
Human   315 QAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQH---QPSPMARPLTVDE 376

  Fly   306 IREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLD 370
            |..:...|:..|.:..::.:|.|.|.:|.:|:.|:::..|:. |......||...:..:.|.|||
Human   377 IVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVD-VFKEKHMAPEFCSLEEGLPYLD 440

  Fly   371 CVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLED 435
            .||.||:|:|||.....|.|.::.|:..:.|||...:.:.:...|.|..::|.|.:|.||||..:
Human   441 MVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAE 505

  Fly   436 QEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGIN 500
            ..|.|..|.|:||.|||::|:|.:..:||:|:.:..||..:......|...| |....:||.|..
Human   506 ARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVP-LQLESKSALGPK 569

  Fly   501 VGL 503
            .|:
Human   570 NGV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	118/481 (25%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	125/531 (24%)