DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	452	Identity:	148/452 - (32%)
Similarity:	244/452 - (53%)	Gaps:	30/452 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YGKTFRFWILGESLIYTKDLQYFETILS----STTLLEKGQLY-EYLRPFLNDGLLVSTGRKWHA 126
            |.:.|..| ||..:.:.. |.:.:||.|    |..:..|..|: .:|:|:|.:|:|:|.|.||..
Human    84 YSQGFTVW-LGPIIPFIV-LCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSR 146

  Fly   127 RRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVA-DGKTAVDMLKYVSLAALDVITEAAMGVQ 190
            .|::.|.||||.:|:.|:.|.::.:::|:|..:.:| :|.:.:||.:::||..||.:.:......
Human   147 HRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFD 211

  Fly   191 VNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLH--RQLLSDIRVMHDFTDKVI 253
            .:.|..|. .||..:..:..:...|.....:..::|:.|:    |  |:.....|::|||||.||
Human   212 SHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLS----HDGRRFHRACRLVHDFTDAVI 271

  Fly   254 SERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----ILLQSSINNQPLSDADIREEVDTFM 314
            .|||.|:.....|..::          .|::...||    :||....:.:.|||.|||.|.||||
Human   272 RERRRTLPTQGIDDFFK----------DKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFM 326

  Fly   315 FEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRL 379
            |.|.|||:||:|..||.:|||||.|:|..:|:|.:|.......:....|..|.:|...:||::||
Human   327 FGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRL 391

  Fly   380 YPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTF 443
            :||.|.|.|...:::.:.| :.||...:..:.:...|.:...:|||..:.|.||..:..:|.:..
Human   392 HPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPL 456

  Fly   444 AYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGINVGLRP 505
            |::||||||:|||||.||:.||||:::.:|..:..||...|.:..|..|:|:..|:.:.:.|
Human   457 AFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	144/438 (33%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	144/438 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750