DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	540	Identity:	167/540 - (30%)
Similarity:	262/540 - (48%)	Gaps:	76/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 W-LTLITG-----ALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILG--CGLQALHLGAENIIG 58
            | |.|:.|     |.:|..|:.|....:|:..|     |.|   |...  .|.|.|....|..:.
Human    19 WLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCF-----PQP---PKQNWFWGHQGLVTPTEEGMK 75

  Fly    59 WVGEKFDKYGKTFRFWILGES--LIYTKDLQYFETILSSTTLLEKGQL--YEYLRPFLNDGLLVS 119
            .:.:....|.:.|:.| ||.:  |:..........|.|::..:....:  |.:|:|:|.||||:|
Human    76 TLTQLVTTYPQGFKLW-LGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLS 139

  Fly   120 TGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVA-DGKTAVDMLKYVSLAALDVIT 183
            .|.||...|::.|.||||.:|:.|::|.::..::|.|..:::| :|...:||.:::||..||.:.
Human   140 GGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQ 204

  Fly   184 EAAMGVQVNAQNDPDFPYIKALKS------------------VVYIQPDRMFRFSRRYNWLFPLA 230
            :.....:.|.|..|. .||.|:..                  :.|:.||.. ||.|.
Human   205 KCVFSFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQ-RFRRA-------- 259

  Fly   231 APLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----IL 291
                       ..::|||||.||.|||.|:          |....|..:.:|::...||    :|
Human   260 -----------CHLVHDFTDAVIQERRCTL----------PTQGIDDFLKNKAKSKTLDFIDVLL 303

  Fly   292 LQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASA 356
            |....:.:.|||.|||.|.|||||||.|||:||:|..||.:|:|||.|::..:|:|.:|......
Human   304 LSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPI 368

  Fly   357 PVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANY 420
            .:....|..|.:|...|||::||:||||.|.|...::..:.| :.||......:.:...|.:...
Human   369 EIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTV 433

  Fly   421 FPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEEL 485
            :|||..:.|.||.::..:..:..|::||||||:|||||.||:.||||:::..|..:.:||...|.
Human   434 WPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEP 498

  Fly   486 KPMLNFILRSASGINVGLRP 505
            :.....|||:..|:.:.:.|
Human   499 RRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	152/488 (31%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	152/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750