DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cyp4d20 and cyp3c4

DIOPT Version :9

Sequence 1:NP_647723.2 Gene:Cyp4d20 / 38311 FlyBaseID:FBgn0035344 Length:510 Species:Drosophila melanogaster
Sequence 2:NP_001071016.1 Gene:cyp3c4 / 558541 ZFINID:ZDB-GENE-060929-96 Length:507 Species:Danio rerio


Alignment Length:524 Identity:136/524 - (25%)
Similarity:241/524 - (45%) Gaps:52/524 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFDK 66
            | ||:  .|::.|.:.:|....|.  |.|..||||...|.:|..|..    |:.:..:..|...|
Zfish    11 W-TLV--VLVITLLFIYGVWPHRF--FIKLGIPGPRPWPFVGTLLSY----AKGLCNFDMECAKK 66

  Fly    67 YGKTFRFWILGESLIYTKDLQYFETIL----SSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHAR 127
            |||.:..:.....::...||:..:.:|    .|..:..:.:......|| :||:::....:|...
Zfish    67 YGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPF-SDGIIMVKDERWKRM 130

  Fly   128 RKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVN 192
            |...:..|....|:....|...|:...:.|::| .|.:..|.:.:.|:..:|||||.::..|.::
Zfish   131 RSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQK-KDPEQPVKIKEVVAPYSLDVITSSSFSVDID 194

  Fly   193 AQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFP-LAAPLLHRQLLSDIRVMHDFTDKVISER 256
            :.|:|:.|::..:|..:..   .||........||| ||.||....:....:...||...|:.:.
Zfish   195 SINNPEDPFVINVKKFIQF---NMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKKI 256

  Fly   257 RETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREE-----VD----- 311
            ::                 |....|:.::..|.::||:.|.:..:.|:|..|:     .|     
Zfish   257 KD-----------------DHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILS 304

  Fly   312 ---TFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVI 373
               .|:..|.:|||:.::..||.:|.:|:..:::.||:.:....|  .|:|...|..:.||:..|
Zfish   305 QSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLD--TPITYDALMRMDYLEMAI 367

  Fly   374 KETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQ 438
            .|:|||.|..|.:.|.|:|.:.|...|||..|.:.:..|....|.:.:..|..||||||..:.:.
Zfish   368 NESMRLLPTAPRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKS 432

  Fly   439 GHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPM-LNFILRSASGINVG 502
            ....:|::||..||:||||.::||:.||:.:.|:|:.:.:....|...|: :|...:....|.:.
Zfish   433 EFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVTFQPKVPITLK 497

  Fly   503 LRPR 506
            |.||
Zfish   498 LIPR 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp4d20NP_647723.2 p450 34..493 CDD:278495 122/477 (26%)
cyp3c4NP_001071016.1 p450 38..485 CDD:278495 121/474 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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