DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d20 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	169/534 - (31%)
Similarity:	268/534 - (50%)	Gaps:	86/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITGALILLL-TWDFGRKRQRVL-AFEKSAIPGPISIPILGCGLQALHLGAENIIGWV-------G 61
            :.|.|:||: ...|..:||.:| ||::  .|.|           ..|        |.       |
  Rat    24 VLGLLLLLVKAVQFYLQRQWLLKAFQQ--FPSP-----------PFH--------WFFGHKQFQG 67

  Fly    62 EK--------FDKYGKTFRFWILGES---LIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDG 115
            :|        .:.:...|..|..|..   ::|..|  |.:.||..:.....| :|..|.|::..|
  Rat    68 DKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPD--YMKVILGRSDPKANG-VYRLLAPWIGYG 129

  Fly   116 LLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALD 180
            ||:..|:.|...|::.|.|||:.:|:.||:.|.....:|:|...::|...:::::.:::||..||
  Rat   130 LLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLD 194

  Fly   181 VITEAAMGVQVNAQNDPDF-PYIKALKSV----------VYIQPDRMFRFSRRYNWLFPLAAPLL 234
            .:.:.|.....:.|.|.:: .||:|:.::          ::.|.|.::.||.. ..||..|..|
  Rat   195 TVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSN-GHLFNRACQL- 257

  Fly   235 HRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAE-IGSKSQMALLDILLQSSI-N 297
                      .||.||.||..|::.::.|           |:.| :..|.::..|||||.:.: |
  Rat   258 ----------AHDHTDGVIKLRKDQLQNA-----------GELEKVKKKRRLDFLDILLLARMEN 301

  Fly   298 NQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ 362
            ...|||.|:|.|||||||||.|||:||||...||:|.|||.|||..||:|.|||..:|  :|...
  Rat   302 GDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGSS--ITWDH 364

  Fly   363 LQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLS 426
            |..:.|....|||.:|||||||.|.|.....:...| :::|....:.|.:|..|.:...:|:|..
  Rat   365 LDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEV 429

  Fly   427 FRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELK-PMLN 490
            |.|.||..|..:  ::.:::|||.|.:||||::||:.||||:::..|..:||||...::. |:..
  Rat   430 FDPSRFAPDSPR--HSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPR 492

  Fly   491 FILRSASGINVGLR 504
            .:|:|.:||.:.|:
  Rat   493 LVLKSKNGIYLYLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	154/491 (31%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	158/499 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850