DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d20 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	165/554 - (29%)
Similarity:	261/554 - (47%)	Gaps:	95/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LILLLTWDFGRKRQRVLAFEKSAIPGPISIP----ILGCGLQALHLGAENIIGWVGEKFDKYGK- 69
            |.|.|:| .||              ||:::.    :|..|...|   ...|:.|:...:|.|.:
  Rat     2 LQLSLSW-LGR--------------GPVTVSPWQLLLVVGTSLL---LARILAWISAFYDNYCRL 48

  Fly    70 ------TFRFWILGE------------------------------------SLIYTKDLQYFETI 92
                  ..|.|..|.                                    .||:.|   :...|
  Rat    49 RCFPQPPSRHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPK---FIGPI 110

  Fly    93 LSSTTLLEKGQL--YEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMV 155
            |.:...:...::  |.:|:|:|.||||||.|.||..:|::.|.||||.:|:.||:..::..::|.
  Rat   111 LQAPAAVAPKEMIFYGFLKPWLGDGLLVSAGEKWSRQRRLLTPAFHFDILKPYVKNFNKSVNIMH 175

  Fly   156 DNLRKV-ADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKA---LKSVVYIQPDRM 216
            ...::: |.|...:||.:::||..||.:.:.......|.|..|. .||.|   |.|::..:..:.
  Rat   176 AKWQRLTAKGSARLDMFEHISLMTLDSLQKCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQP 239

  Fly   217 FRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGS 281
            |.:   .::|:.|.|.  .|:......::|:|||.||.|||.|:.....|...:          |
  Rat   240 FLY---MDFLYYLTAD--GRRFRKACDLVHNFTDAVIRERRRTLSSQSVDEFLK----------S 289

  Fly   282 KSQMALLD----ILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRI 342
            |::...||    :||....:.:.|||.|||.|.|||||.|.|||:|.:|..||.:|||||.|:|.
  Rat   290 KTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEHQERC 354

  Fly   343 FEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTS 406
            .:|::.:|.......:....|..|.:|...|||::||:|||..|.|...:::.:.| :.||....
  Rat   355 RQEVRELLRDREPEEIEWDDLTQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGND 419

  Fly   407 IYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISK 471
            ..:.::..|.:.:.:|||..:.|.||..:..|..:..|::||||||:|||||.||:.||||.::.
  Rat   420 CIISIFGVHHNPSVWPDPEVYDPFRFDSENPQKRSPLAFIPFSAGPRNCIGQTFAMNEMKVAVAL 484

  Fly   472 VLRFYELLPLGEELKPMLNFILRSASGINVGLRP 505
            .|..:.|||..:|.:.....|||:..|:.:.:.|
  Rat   485 TLLRFRLLPDDKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	154/516 (30%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	149/480 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348609
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750