DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d20 and Cyp4d14

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	241/526 - (45%)
Similarity:	340/526 - (64%)	Gaps:	38/526 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEK-- 63
            |:|.|....|...|.||:.|||:....:.::.|.||.|.|::|           |....:.|.
  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVG-----------NAPLLINESPK 54

  Fly    64 -----FD-------KYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGL 116
                 ||       ::||..:..:||||...|.|.:..|.|:||...::|..||..|..:|.|||
  Fly    55 SKSSIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGL 119

  Fly   117 LVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDV 181
            |:|.|:||..||||.|.|||||:||.:||:.|:.|:.||..|...|||||.::|.....|.|:|:
  Fly   120 LISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDI 184

  Fly   182 ITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMH 246
            |.|.||||::|||..|.|.|::::.:...:..:|.....:|.::...|..|.|..:|...::.||
  Fly   185 IAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMH 249

  Fly   247 DFTDKVISERRETVRRAKADGTYRPLSLGDA------EIGSKSQMALLDILLQSSINNQPLSDAD 305
            |||:.||:||||.:::|.|||       |||      ::|.|.:|||||:||:|:|:..|||:.|
  Fly   250 DFTNSVITERRELLQKAIADG-------GDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDD 307

  Fly   306 IREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLD 370
            ||||||||||||.|||:|.::...|.:|||||||.|:|:|::.|:|.|.|||||...|.:||||:
  Fly   308 IREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLE 372

  Fly   371 CVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLED 435
            |||||::||:|.||.|||:..::..:..|.|||::::.:::|:|.||.:|||||..|.|:||..:
  Fly   373 CVIKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSME 437

  Fly   436 QEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGIN 500
            ::...:.|||.||||||:||||||||:||||..|||::|.:||||||||::|:||.||||.:|||
  Fly   438 RKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGIN 502

  Fly   501 VGLRPR 506
            .||:||
  Fly   503 CGLKPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	219/478 (46%)
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	216/472 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448999
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	1	1.000	-	-		H82150
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	12	11.910