DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d20 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	130/546 - (23%)
Similarity:	233/546 - (42%)	Gaps:	102/546 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGW-----VGEKF 64
            |:...::::|:......|:|...:::..||.....|:.|           ||..|     :.|.|
  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFG-----------NIKDWPNKRHIAEIF 55

  Fly    65 DKYGKTFR---------FWILGESLIYT----------KDLQYFETILSSTTLLEKGQLYEYLRP 110
            ..|...::         |:....:.:.|          ||..:||         .:|..|..:..
  Fly    56 RDYYFKYKNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFE---------NRGVFYNEIDD 111

  Fly   111 FLNDGLLVSTGRKW-HARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVD---ML 171
            .|:..|....|:|| |.|.|: |..|....:::...|:.:    :.:.:.||...|||.|   :|
  Fly   112 PLSATLFSIEGQKWRHLRHKL-TPTFTSGKMKNMFPIVVK----VGEEMDKVFRSKTAADRGQVL 171

  Fly   172 KYVSLAA---LDVITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRY-NWL--FPLA 230
            :.|.|.|   .|||...|.|:..|:..||...::...|..:         ...|| |.|  |...
  Fly   172 EVVDLVARYTADVIGNCAFGLNCNSLYDPKAEFVSIGKRAI---------TEHRYGNMLDIFLFG 227

  Fly   231 APLLHRQLLSDIRVM--HDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQM-ALLDILL 292
            .|.|.|:|...:.:.  .||..|::   |||:               |..:.:|.:. ..:|.|:
  Fly   228 FPKLSRRLRLKLNIQEAEDFYTKIV---RETI---------------DYRLRTKEKRNDFMDSLI 274

  Fly   293 QSSINNQP------LSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLG 351
            :...|.|.      |:..::..:...|...|.:|:|:.:..|||.:||:.:||.::.||:..|.|
  Fly   275 EMYKNEQSGNSEDGLTFNELLAQAFIFFVAGFETSSTTMGFALYELARNQDVQDKLREEIGNVFG 339

  Fly   352 PDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKT--IPANTSIYLVLYYA 414
            .. :...|...::::|||:.|:.||:|.||.:..:.|....:....|..  |...|.:.:.....
  Fly   340 KH-NKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTDTDFSPEDPKYFIAKGTIVVIPALGI 403

  Fly   415 HRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELL 479
            |.|.:.:|:|..|:||||.:::.....:..::||..||:||||.:|.:::..|.::.::|.|:..
  Fly   404 HYDPDIYPEPEIFKPERFTDEEIAARPSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFS 468

  Fly   480 PLGEELKPM----LNFILRSASGINV 501
            ...|...||    .|.::.:.:||::
  Fly   469 VSPETQIPMKIVVKNILISAENGIHL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	123/507 (24%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	120/494 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910