DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and sad

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	126/573 - (21%)
Similarity:	228/573 - (39%)	Gaps:	135/573 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLT-LITGALILLLTWDFGRKR------QR--------VLAFEKSAIPGPISIPILGCGLQALHL 51
            ||. |:...|:.:|:....|.|      ||        .:|.:...||....:|::|..:..:..
  Fly    13 WLRHLLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAA 77

  Fly    52 -GAENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLL-----EKGQLYEYLRP 110
             ||.::..::..:..:||..||     |.|..|:|..:    :||..|:     .:||..::..|
  Fly    78 GGATHLHKYIDARHKQYGPIFR-----ERLGGTQDAVF----VSSANLMRGVFQHEGQYPQHPLP 133

  Fly   111 ----FLND------GLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRH----SSVMVDNLRKV 161
                ..|.      ||....|.:|...|:|....    :|...:..||.|    :..|||..::.
  Fly   134 DAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRL----LLNGNLNWMDVHIESCTRRMVDQWKRR 194

  Fly   162 ADGKTAVDMLKYVSLA--------------ALDVITEAAMGVQV----NAQNDPDFPYIKALKSV 208
            .....|:.:.:...:.              :::|:.....|..|    ..|:..|:     ...:
  Fly   195 TAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDY-----FTQI 254

  Fly   209 VYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDF---TDKVISER----------RETV 260
            |:    ::|..|.|.....|..|.:|.      :.:..||   .|:|:.|.          :|..
  Fly   255 VH----KVFEHSSRLMTFPPRLAQILR------LPIWRDFEANVDEVLREGAAIIDHCIRVQEDQ 309

  Fly   261 RRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGV 325
            ||...:..|..|...|.. |...:...:|:::.:.                       |||:...
  Fly   310 RRPHDEALYHRLQAADVP-GDMIKRIFVDLVIAAG-----------------------DTTAFSS 350

  Fly   326 SHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHA 390
            ..||:|:::.|.:|||:.:|               ....|.:.:..:|||::||||..|.|||:.
  Fly   351 QWALFALSKEPRLQQRLAKE---------------RATNDSRLMHGLIKESLRLYPVAPFIGRYL 400

  Fly   391 QKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERF-LEDQEQGHNTFAYVPFSAGPKN 454
            .::.::|...|..:|.:.|.||.|.||.::|..|....|||: :.:.||.|.:...:||:.|.::
  Fly   401 PQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRS 465

  Fly   455 CIGQKFAVLEMKVLISKVLRFYELLPLGE-ELKPMLNFILRSASGINVGLRPR 506
            |||::.|:.::..|:.:....:|:..|.| .:..:|..:......:.:.||||
  Fly   466 CIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRPR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	111/511 (22%)
sad	NP_650123.1	p450	63..497	CDD:299894	109/500 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010