DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	510	Identity:	155/510 - (30%)
Similarity:	257/510 - (50%)	Gaps:	47/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITGALILLL-TWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFDKYGK 69
            :.|.|:||| :..:...||.::...:...|.|....:.|..|:...|  :.|:..|    :|:..
Mouse    24 LLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGNTLKDQDL--QQILLCV----EKFPS 82

  Fly    70 TFRFWILGES---LIYTKDLQYFETIL--SSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARRK 129
            |:..|:.|..   :||..|  |.:.||  |...::..   |.:..|::..|||:..|:||...|:
Mouse    83 TYVRWLWGNHARVVIYDPD--YMKVILGRSDPKVVRS---YSFFAPWIGYGLLLLNGKKWFQHRR 142

  Fly   130 IFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQ 194
            :.|.|||:.:|:.||.||.....||:|...::.|....:::.:.:||..::.:.:.|...|.:.|
Mouse   143 MLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQ 207

  Fly   195 NDP---DFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISER 256
            .:.   ...||||::.:.::...|:.....:.|.::.|::.  .|......::.|..|::||..|
Mouse   208 LEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSN--GRSFYHACQIAHKHTERVIRMR 270

  Fly   257 RETVRRAKADGTYRPLSLGDAEI---GSKSQMALLDILL-QSSINNQPLSDADIREEVDTFMFEG 317
            :..::             .:||:   ..|.::..||||| ..:.:.:.|||.|:|.|:|||||||
Mouse   271 KAQLQ-------------NEAELEKFRKKKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEG 322

  Fly   318 DDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPP 382
            .:||:||:|...||:|.|||.|||..||::.:||...|  ||...|..:.|....|||.:|||||
Mouse   323 HNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTS--VTLNHLDQMPYTTMCIKEALRLYPP 385

  Fly   383 VPAIGRHAQKELEIGDK-TIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYV 446
            :|...|.....:...|. ::|....:.|..|..|.:....|:...|.|.||.....:  .|.|::
Mouse   386 IPGASRELSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAPGAPR--QTHAFL 448

  Fly   447 PFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPML--NFILRSASGI 499
            |||||.:||||::|.:.|:||.::..|..:||||....: |:|  ..:|:|.:||
Mouse   449 PFSAGTRNCIGKQFTMNELKVAVALTLLRFELLPDPTRV-PILVSKIVLKSKNGI 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	144/473 (30%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	146/475 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750