DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	533	Identity:	170/533 - (31%)
Similarity:	269/533 - (50%)	Gaps:	84/533 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHL--------GAENIIGWVG 61
            |:|...:|::      :|:.|...|:  .|||.:..:.|      |:        ..|.|:.|:
Zfish    25 LLTVVKLLIV------RRKGVKTMER--FPGPPAHWLFG------HVKEFRQDGHDLEKIVKWM- 74

  Fly    62 EKFDKYGKTFRFWILGESL--IYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKW 124
               :.|...|..| .|.||  :......|.:||| :||..:....|::..|:|.||||||||:||
Zfish    75 ---ELYQFAFPLW-FGPSLAVLNIHHPSYVKTIL-TTTEPKDDYAYKFFIPWLGDGLLVSTGQKW 134

  Fly   125 HARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGV 189
            ...|::.|..||:.||:.||:::...:.||:|.....:..:.:.::.|:|||..||.|.:.|...
Zfish   135 FRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSC 199

  Fly   190 QVNAQNDPDF-PYIKAL------------------KSVVYIQPDRMFRFSRRYNWLFPLAAPLLH 235
            ..|.|.|... |||:|:                  |::.::.|         :.:.|..||
Zfish   200 NSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSP---------HGYRFRKAA---- 251

  Fly   236 RQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQS-SINNQ 299
                   .:.|:.|.:||.:|:|.::..:..|.          :.::..:..|||||.: ..:.|
Zfish   252 -------SIAHNHTAEVIRKRKEVLKMEEEQGI----------VKNRRYLDFLDILLSARDEHQQ 299

  Fly   300 PLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQ 364
            .|||.|||.|||||||||.|||:||:|...|.:|.:||.|::..:|:|:.|  |..|.:....|.
Zfish   300 GLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQAL--DGKATLEWEDLN 362

  Fly   365 DLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFR 428
            .:.|....|||::||:||||.|.|...|.|...| :|:|...:|.:.:|..|.::..:.:|..|.
Zfish   363 KIPYTTMCIKESLRLHPPVPGISRKLTKPLTFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFD 427

  Fly   429 PERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPML-NFI 492
            |.|||.:.....:..|:|||||||:|||||.||:.||||.::..|:.|.|:...:....|: ..:
Zfish   428 PLRFLPENVANRSPHAFVPFSAGPRNCIGQNFAMNEMKVAVALTLKRYYLIKDPDHTPKMIPQVV 492

  Fly   493 LRSASGINVGLRP 505
            |||.:||::.::|
Zfish   493 LRSLNGIHIKIKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	158/490 (32%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	163/498 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750