DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp6a19

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	131/558 - (23%)
Similarity:	221/558 - (39%)	Gaps:	122/558 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTLITGALILLLTWDFGRKRQRVLAFEKSAIP-GPISIPILGCGLQALHLGAENIIGWVGEKFDK 66
            |.|:.|.|.|:..|..    |....:::..|| .|.:||:...|.....:....|:.....||.|
  Fly     5 LGLVVGVLTLVAWWVL----QNYTYWKRRGIPHDPPNIPLGNTGELWRTMPLAGILKRTYLKFRK 65

  Fly    67 Y--GKTFRFWILGESLIYTKDLQYFETIL--SSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHAR 127
            .  |....|::.....|...|:.:.:|:|  ......::|..:......|.:.|....|:||...
  Fly    66 QTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATIEGQKWKNL 130

  Fly   128 RKIFTHAFH-----------FKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDV 181
            |:..||.|.           ..|.:..:.::|          .|::.....:::...||....||
  Fly   131 RQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVD----------EKISSSSQTLEVTDIVSRFTSDV 185

  Fly   182 ITEAAMGVQVNAQNDPDFPYIK----ALKSVVYIQPDRMFRFSRRYNWLF--------PLAAPLL 234
            |...|.|::.|:..||...:::    ||:             .||:.||.        .||..|.
  Fly   186 IGICAFGLKCNSLRDPKAEFVQMGYSALR-------------ERRHGWLVDLLIFGMPKLAVKLG 237

  Fly   235 HRQLLSDIR-------------------VMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIG 280
            .:.||..::                   ..:||.|.:|..:::             ...||.|.|
  Fly   238 FQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQ-------------YDKGDKENG 289

  Fly   281 SKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEE 345
                :|..::..|:.:                |...|.:..|:.:...||.:|.:.:||.::..|
  Fly   290 ----LAFNEVAAQAFV----------------FFLAGFEAGSTTMGFTLYELACNQDVQDKLRAE 334

  Fly   346 LQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKT--IPANTSIY 408
            :..|| ...:..:....:|||.|::.||.|::|.:|.|..:.|.|.|..:..:..  |.|.|.:.
  Fly   335 IDSVL-ERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVL 398

  Fly   409 LVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVL 473
            :.....|.|..::|:|..|.||||.|:|.:...|.|::||.|||:||||.:|.  .|:|:|...|
  Fly   399 VSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFG--RMQVIIGLAL 461

  Fly   474 RF----YELLPLGEELKPML----NFILRSASGINVGL 503
            ..    :||.|  :...||.    |.:|.|..||::.:
  Fly   462 LIHNFRFELHP--KTPVPMKYTINNLLLGSEGGIHLNI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	119/515 (23%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	123/523 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910