DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	190/508 - (37%)
Similarity:	297/508 - (58%)	Gaps:	30/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TGALILLLTW-DFGRKRQRVLAFEK-----SAIPGPISIPILGCGLQALHLGAENIIGWVGEKFD 65
            |.||:..:.| .|.|...::|.|.:     ..:|||.      .|....::....|:.|:.|..:
  Fly     3 TLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPT------IGELIANVKKGEILNWLKELRE 61

  Fly    66 KYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARRKI 130
            |:|..||.|...:.::...|.:..:.:|.:..||.|.:.||.|.|:|..|||.:.|..||.|||:
  Fly    62 KHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKL 126

  Fly   131 FTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQN 195
            .|..|||::|..:.|.|:.:..::|..||..|:|: :.|:..|::|.|||.|.|.|||::.:||.
  Fly   127 LTPGFHFRILSEFKEPMEENCRILVRRLRTKANGE-SFDIYPYITLFALDAICETAMGIKKHAQL 190

  Fly   196 DPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETV 260
            ..|..|::|::|:..:...:.|.|.:|.|..|....|...|:  :.::|:||.|::||..|||.:
  Fly   191 QSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKERE--AALKVLHDETNRVIRLRREQL 253

  Fly   261 RRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSI-NNQPLSDADIREEVDTFMFEGDDTTSSG 324
            .:.:.:  ::|.:..| ::|:|.::|.||:||.:.: ....|||.|||||||||||||.|||||.
  Fly   254 IQERNE--WKPEAEQD-DVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSA 315

  Fly   325 VSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRH 389
            ::.||..::::|:||||.|||...:.|         .:.:.:.||:.|||||:|:||.||...|.
  Fly   316 IAFALSLLSKNPDVQQRAFEEASELEG---------REKESMPYLEAVIKETLRIYPSVPFFSRK 371

  Fly   390 AQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKN 454
            ..::||:|..|:|...||..::|..|||...||||..|.|:|||.:::|.| .||:..|||||:|
  Fly   372 VLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMH-PFAFAAFSAGPRN 435

  Fly   455 CIGQKFAVLEMKVLISKVLRFYELLP-LGEELKPMLNFILRSASGINVGLRPR 506
            |||||||:||:|..::.:||.|..|| ...:.||:...:.:|.:||.:.:.||
  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILPR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	177/460 (38%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	175/455 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460464
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910