DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	160/516 - (31%)
Similarity:	254/516 - (49%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFD 65
            :|..|    ||.|..|...||  ..|....|::|||.:.|:||.......|..|.|.....|..|
  Fly     3 LWPLL----LITLTIWILVRK--WTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRD 61

  Fly    66 KYGKTFR------FWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKW 124
            ::|.|:|      .|:...|...|:...:..|:..:.|.::       |.|.:.:|||:|.|..|
  Fly    62 RFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKADTFMQ-------LEPLIGNGLLISHGAHW 119

  Fly   125 HARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTA---VDMLKYVSLAALDVITEAA 186
            ..:|::.|.||..::|..:...:..|...:|..|     |.|.   :::.:.:....||.|.:.:
  Fly   120 TRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL-----GATRGAFLEVTEPLFACLLDAIVDTS 179

  Fly   187 MGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDK 251
            ||.|::.|:....|.|:|......:...||.......:|:|....  |.|.|...::|:|...:.
  Fly   180 MGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQ--LWRDLDEQLQVIHSQMES 242

  Fly   252 VISERRETVRRAKADGTYRPLSLGDAEIGSKSQMA--LLDILLQSSINNQPLSDADIREEVDTFM 314
            ||.:|.:.:                .::|..:..|  |||.||.:....|.||..:||:|::||:
  Fly   243 VIEKRAKEL----------------LDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFV 291

  Fly   315 FEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ-LQDLKYLDCVIKETMR 378
            |.|.|||::.:|..|||:|:.||.|.|:.:|||.|    |....|... |..|.||:.:|||.:|
  Fly   292 FAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDV----ALDETTDLDALNGLPYLEALIKEVLR 352

  Fly   379 LYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFL-EDQEQGHNT 442
            ||..||..||...:..|||.:|..|..::::.:|....|..|:|||.:|:|||:| ||.......
  Fly   353 LYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPA 417

  Fly   443 FAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFY--ELLPLGEELKPMLNFILRSASGINV 501
            |:|:|||.||..|||:::::|.||:|.::::|.:  ||.|....|:.....:|::..||||
  Fly   418 FSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	145/473 (31%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	150/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	7.960