DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	531	Identity:	159/531 - (29%)
Similarity:	267/531 - (50%)	Gaps:	57/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITGALILLLTWDFGR---------KRQRVLAFEKSAIPGPISIPILGCGLQALHL----GAEN-- 55
            :..||:||:.:.|.|         ...|:...:.|..|.|.....| .|..:::|    |.:|
Mouse    23 VVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWL-LGHMSMYLPNEKGLQNEK 86

  Fly    56 ---------IIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETIL-SSTTLLEKGQ-LYEYLR 109
                     |:.|||...              .|:......|.:.:| :|..:..|.: .|.:|:
Mouse    87 KVLDTMHHIILAWVGPFL--------------PLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLK 137

  Fly   110 PFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRK-VADGK-TAVDMLK 172
            |:|.||||:|.|.||...|::.|.||||.:|:.|::|.::.:::|....|: :|:|. |:.||.:
Mouse   138 PWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVTSFDMFE 202

  Fly   173 YVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQ 237
            ::||..||.:.:.......:.|.... .||.::..:..:...|.:|.....::::.|.|.  .|:
Mouse   203 HISLMTLDSLQKCVFSYNSDCQERMS-DYISSIIELSALVVRRQYRLHHYLDFMYYLTAD--GRR 264

  Fly   238 LLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDI-LLQSSINNQPL 301
            .......:|:||.:||.|||:.:|:..|:...:      |:.|  ..:..:|: ||......:.|
Mouse   265 FRQACDTVHNFTTEVIQERRQALRQQGAEAWLK------AKQG--KTLDFIDVLLLAKDEEGKEL 321

  Fly   302 SDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDL 366
            ||.|||.|.|||||||.||||||:|.||:.:|::||.|::..||:|.|:.......:....|..|
Mouse   322 SDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQL 386

  Fly   367 KYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPE 430
            .:....|||::|.:|||..|.|...:::::.| :.||......:.:|..|.:...:||...:.|.
Mouse   387 PFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPKGIICLVSIYGTHHNPIVWPDSKVYNPY 451

  Fly   431 RFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLIS-KVLRFYELLPLGEELKPMLNFILR 494
            ||..|..|..:..|:|||||||:|||||.||:.||:|::: .:|||...:....:::.....|||
Mouse   452 RFDPDTPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILR 516

  Fly   495 SASGINVGLRP 505
            :.:|:.:.:.|
Mouse   517 TENGLWLNVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	146/480 (30%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	146/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750