DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp26b1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_851601.2	Gene:	Cyp26b1 / 312495	RGDID:	631379	Length:	512	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	124/519 - (23%)
Similarity:	202/519 - (38%)	Gaps:	74/519 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFDKY 67
            |.|.....:..|.|...|.:...|...|    |.:..|::|.....|..|:    |:...:.:||
  Rat    24 LLLAVSQQLWQLRWAATRDKSCKLPIPK----GSMGFPLIGETGHWLLQGS----GFQSSRREKY 80

  Fly    68 GKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLV-STGRKWHARRKIF 131
            |..|:..:||..||.....:....||.....|...:.....|..|....:. |.|.....:||:|
  Rat    81 GNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVF 145

  Fly   132 THAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQND 196
            :..|..:.||.|   :.:...|:.|.||..:....|:::.:........:.....:|..:..::.
  Rat   146 SKIFSHEALESY---LPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDL 207

  Fly   197 PDF--PYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRET 259
            .:.  .|.:.:::|..:..|..|...||         .:..||:|      ....:|.|.|:.:.
  Rat   208 GNLFEVYQQFVENVFSLPVDLPFSGYRR---------GIQARQIL------QKGLEKAIREKLQC 257

  Fly   260 VRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSS------INNQPLSDADIREEVDTFMFEGD 318
            .:                   .|.....||||::||      :..|.|.|..:.     .:|...
  Rat   258 TQ-------------------GKDYSDALDILIESSKEHGKEMTMQELKDGTLE-----LIFAAY 298

  Fly   319 DTTSSGVSHALYAIARHPEVQQRIFEEL--QRVL---GPDASAPVTQAQLQDLKYLDCVIKETMR 378
            .||:|..:..:..:.:||.|.:::.|||  |.:|   |......:....|..|:||||||||.||
  Rat   299 ATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDMLSGLRYLDCVIKEVMR 363

  Fly   379 LYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQ-EQGHNT 442
            |:.||....|...:..|:....||...|:...:...|..|..|.|...|.|:||.:.: |.....
  Rat   364 LFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGR 428

  Fly   443 FAYVPFSAGPKNCIGQKFAVLEMKVL---ISKVLRFYELLPLGEELKPMLNF--ILRSASGINV 501
            |.|:||..|.:.|:|:..|.|.:|||   ::...||    .|.....|.:..  :|....|::|
  Rat   429 FHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRF----ELATRTFPRITLVPVLHPVDGLSV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	114/478 (24%)
Cyp26b1	NP_851601.2	CYP26B1	60..490	CDD:410730	115/479 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910