DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp26c1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_217935.3	Gene:	Cyp26c1 / 308190	RGDID:	1308843	Length:	518	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	126/513 - (24%)
Similarity:	199/513 - (38%)	Gaps:	101/513 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LITGALILL------LTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWV--G 61
            |..|.|:.|      |.|...|.....|...|    |.:..|..|   :.||        |:  |
  Rat    20 LCAGLLLGLAQQLWTLRWTLSRDWASTLPLPK----GSMGWPFFG---ETLH--------WLVQG 69

  Fly    62 EKF-----DKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFL-NDGLLVST 120
            .:|     ::||..|:..:||..:|.....:...|||.....|.:.|..:.....| :..||.:.
  Rat    70 SRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAV 134

  Fly   121 GRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEA 185
            |.:...|||:....|....||.:|   .|....:...:|.....:..|.:.:........:....
  Rat   135 GERHRQRRKVLARVFSRPALEQFV---PRLQEALRREVRSWCAAQRPVAVYQAAKALTFRMAARI 196

  Fly   186 AMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRV---MHD 247
            .:|:|::.....:...                .|.|....||.|...:....|...||.   ::.
  Rat   197 LLGLQLDEARCTELAQ----------------TFERLVENLFSLPLDVPFSGLRKGIRARDQLYQ 245

  Fly   248 FTDKVISER-RETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSIN-NQPLSDADIREEV 310
            ..|:||:|: ||.:       |..|   |||          |.:::.|:.. .:.||..:::|..
  Rat   246 HLDEVIAEKLREEL-------TAEP---GDA----------LHLIINSARELGRELSVQELKELA 290

  Fly   311 DTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQ------------RVLG--PDASA--PVT 359
            ...:|....||:|..:..:..:.:||....:|.:||.            |..|  ||.|.  .::
  Rat   291 VELLFAAFFTTASASTSLILLLLQHPAAIAKIQQELSAQGLGSPCSCAPRASGSRPDCSCEPDLS 355

  Fly   360 QAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRD-----AN 419
            .|.|..|:|:|||:||.:||.|||....|.|.:..|:....||...|:    .|:.||     |.
  Rat   356 LAVLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSV----MYSIRDTHETAAV 416

  Fly   420 YFPDPLSFRPERF---LEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLR 474
            |...|..|.||||   .||.......|.|:||..|.::|:||:.|...:::|..:::|
  Rat   417 YRSPPEGFDPERFGVESEDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAVELVR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	117/478 (24%)
Cyp26c1	XP_217935.3	p450	40..500	CDD:299894	120/493 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910