Protein Alignment Cyp4d20 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 190/534 - (35%)
• Similarity: 295/534 - (55%)
• Gaps: 52/534 - (9%)

  Fly     1 MW-----LTLITGALILLLTWDFGRKRQRVLAFEKS-----AIPGPI-SIPILGCGLQALHLGAE 54
            :|     |:|...:|:|.|.       |||.::.:.     .||... :.|::|..|.....|.|
Human    15 LWGAASALSLAGASLVLSLL-------QRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGRE 72

  Fly    55 ---NIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGL 116
               .||.:..|.  ::....:.|:....::...:.:..|.||:|:..::|..:|::|.|:|..||
Human    73 FFQQIIEYTEEY--RHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGL 135

  Fly   117 LVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDV 181
            |.|||.||.:|||:.|..|||.:||.:::||:..::::|..|.|..: :.|.:...|::|.|||:
Human   136 LTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-QEAFNCFFYITLCALDI 199

  Fly   182 ITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLL------HRQLLS 240
            |.|.|||..:.||::.|..|::|    ||...:.:|| ..:..||:.....|:      |::
Human   200 ICETAMGKNIGAQSNDDSEYVRA----VYRMSEMIFR-RIKMPWLWLDLWYLMFKEGWEHKK--- 256

  Fly   241 DIRVMHDFTDKVISERRETVRR---AKADGTYRPLSLGDAEIGSKSQMALLDILLQ-SSINNQPL 301
            .::::|.||:.||:||...:..   .:.||.      |.|...:| :.|.||:||. :......|
Human   257 SLQILHTFTNSVIAERANEMNANEDCRGDGR------GSAPSKNK-RRAFLDLLLSVTDDEGNRL 314

  Fly   302 SDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDL 366
            |..|||||||||||||.|||::.::.:||.:..:||||:::..||..|.| .:..|.|...|:.|
Human   315 SHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG-KSDRPATVEDLKKL 378

  Fly   367 KYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPER 431
            :||:||||||:||:|.||...|...::.|:....:...|...::.|..|||..|||:|..|:|||
Human   379 RYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPER 443

  Fly   432 FLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFY--ELLPLGEELKPMLNFILR 494
            |..:..||.:.:|||||||||:|||||||||:|.|.::|.:||.:  |.....|||......|||
Human   444 FFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILR 508

  Fly   495 SASGINVGLRPRKA 508
            .::||.:.|:.|.|
Human   509 PSNGIWIKLKRRNA 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	168/444 (38%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	171/457 (37%)