Protein Alignment Cyp4d20 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 154/456 - (33%)
• Similarity: 238/456 - (52%)
• Gaps: 48/456 - (10%)

  Fly    69 KTF----RFWILGESL-IYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARR 128
            |||    .:||.|..: :...|..|.:.||..:.....|. |::|.|.:..|||:..|:.|...|
Human    80 KTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPRIGYGLLLLNGQTWFQHR 143

  Fly   129 KIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNA 193
            ::.|.|||..:|:.||.:|.....||:|...::....:.:::.::|||..||.|.::|...|.:.
Human   144 RMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSI 208

  Fly   194 QNDPDF-PYIKA---LKSVVYI-------QPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHD 247
            |.|.:. .||:|   |.|:|:.       :.|.::..:....|        .||.    .::.|.
Human   209 QVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRW--------THRA----CQLAHQ 261

  Fly   248 FTDKVISERRETVRRAKADGTYRPLSLGDAE-IGSKSQMALLDILLQSSI-NNQPLSDADIREEV 310
            .||:||..|:..:::.           |:.| |..|..:..|||||.:.: |...|||.|:|.||
Human   262 HTDQVIQLRKAQLQKE-----------GELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEV 315

  Fly   311 DTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKE 375
            |||||||.|||:||:|..|||:|.||:.|:|..||:..:||..||  :|...|..:.|....|||
Human   316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS--ITWNHLDQMPYTTMCIKE 378

  Fly   376 TMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQG 439
            .:|||||||.|||.....:...| :::|....:.|.:|..|.:...:|:...|.|.||.....|
Human   379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ- 442

  Fly   440 HNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELK-PMLNFILRSASGINVGL 503
             ::.|::|||.|.:||||::||:.::||..:..|..:||||....:. ||...:|:|.:||::.|
Human   443 -HSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRL 506

  Fly   504 R 504
            |
Human   507 R 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	152/451 (34%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	152/452 (34%)