DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	196/543 - (36%)
Similarity:	300/543 - (55%)	Gaps:	63/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLTL---------------ITGALILL----LTWDFGRKRQRVLAFEKSAIPGPI-SIPILGCG 45
            :||.|               :.||.:||    :...:.||.|::     ..||... :.|::|
  Rat     4 LWLGLSGQKLLLWGAASAVSVAGATVLLNILQMLVSYARKWQQM-----RPIPSVARAYPLVG-- 61

  Fly    46 LQALHLGAENIIGWVGEKFD---KYGKTFR------FWILGESLIYTKDLQYFETILSSTTLLEK 101
             .||.:...|.     |.|.   :|.:.||      .||....|:.....:..|.||:|:..::|
  Rat    62 -HALFMKPNNT-----EFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDK 120

  Fly   102 GQLYEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKT 166
            ..:|::|:|:|..|||.|||.||.||||:.|.:|||.:||.::::|:..::::|:.|.|..: :.
  Rat   121 SFMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVN-QE 184

  Fly   167 AVDMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAA 231
            |.:....::|.|||:|.|.|||..:.||::.|..|::    .||...|.::|..:...:.|.|..
  Rat   185 AFNCFFPITLCALDIICETAMGKNIGAQSNGDSEYVR----TVYRMSDMIYRRMKMPWFWFDLWY 245

  Fly   232 PLLH--RQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKS-QMALLDILLQ 293
            .:..  |.....::.:|.||:.||:| |...|:|:.|    .:..|...:.||: :.|.||:||
  Rat   246 LMFKEGRDHKKGLKSLHTFTNNVIAE-RVNARKAEQD----CIGAGRGPLPSKTKRKAFLDLLL- 304

  Fly   294 SSINNQ---PLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDAS 355
             |:.::   .||..|||||||||||||.|||::.::.:||.:..:||||:::.:||..|.| .:.
  Rat   305 -SVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFG-RSH 367

  Fly   356 APVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANY 420
            .|||...|:.|||||||||||:|::|.||...|...::.|:....|...|...::.|..|||..|
  Rat   368 RPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRY 432

  Fly   421 FPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLR--FYELLPLGE 483
            ||||..|:||||..:..||.:.:|||||||||:|||||||||:|.|.:::.:||  :.|.....|
  Rat   433 FPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKRE 497

  Fly   484 ELKPMLNFILRSASGINVGLRPR 506
            ||....:.|||..:||.:.|:.|
  Rat   498 ELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	178/476 (37%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	175/451 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850