DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	157/501 - (31%)
Similarity:	255/501 - (50%)	Gaps:	50/501 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFDKYGKTFRFWILGES 79
            :|.:|.     |...|:...|...|..||...:.:||      .|||..:.         ||  .
  Rat    59 SWFWGH-----LTLMKNNEEGMQFIAHLGRNFRDIHL------SWVGPVYP---------IL--R 101

  Fly    80 LIYTKDLQYFETILSSTTLLEKGQ-LYEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHY 143
            |::...:.  ..:.:|..:..|.. ||.:|:|:|.||||:|.|.||:..|::.|.||||.:|:.|
  Rat   102 LVHPNVIA--PLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHHRRLLTPAFHFDILKSY 164

  Fly   144 VEIMDRHSSVMVDNLRKV-ADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKA--- 204
            |:|.::..:.|....::: |.|...:||.:::||..||.:.:.......|.| :.:..||.|
  Rat   165 VKIFNKSVNTMHAKWQRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDSNCQ-ESNSEYIAAILE 228

  Fly   205 LKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTY 269
            |.|::..:..:.|.:   .::|:.|.|.  .|:......|:|:|||.||.|||.|:.....|...
  Rat   229 LSSLIVKRQRQPFLY---LDFLYYLTAD--GRRFRKACDVVHNFTDAVIRERRSTLNTQGVDEFL 288

  Fly   270 RPLSLGDAEIGSKSQMALLD----ILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALY 330
            :          ::::...||    :||....:.:.|||.|||.|.|||||.|.|||:|.:|..||
  Rat   289 K----------ARAKTKTLDFIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWILY 343

  Fly   331 AIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELE 395
            .:|||||.|:|..:|::.:|.......:....|..|.:|...|||::||:|||..|.|...:::.
  Rat   344 NLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCSQDIV 408

  Fly   396 IGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQK 459
            :.| :.||......:.::..|.:.:.:|||..:.|.||..:..|..:..|::||||||:|||||.
  Rat   409 LPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGPRNCIGQT 473

  Fly   460 FAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGINVGLRP 505
            ||:.|:||.::..|..:.:||..:|.:.....|||:..|:.:.:.|
  Rat   474 FAMSEIKVALALTLLRFCVLPDDKEPRRKPELILRAEGGLWLRVEP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	148/468 (32%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	156/495 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750