Protein Alignment Cyp4d20 and CYP4X1

DIOPT Version :9

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 162/514 - (31%)
• Similarity: 265/514 - (51%)
• Gaps: 50/514 - (9%)

  Fly     9 ALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILG-------CGLQALHLGAENIIGWVGEKFDK 66
            ||.||.......:|||:|. :....|.|.:...||       ..::.|    |.||       :|
Human    23 ALGLLQAIKLYLRRQRLLR-DLRPFPAPPTHWFLGHQKFIQDDNMEKL----EEII-------EK 75

  Fly    67 YGKTFRFWILG--ESLIYTKDLQYFETILSSTTLLEKGQ-LYEYLRPFLNDGLLVSTGRKWHARR 128
            |.:.|.||| |  ::.....|..|.:|:||.|.  .|.| |.::..|.|..||....|.||...|
Human    76 YPRAFPFWI-GPFQAFFCIYDPDYAKTLLSRTD--PKSQYLQKFSPPLLGKGLAALDGPKWFQHR 137

  Fly   129 KIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGK-TAVDMLKYVSLAALDVITEAAMGVQVN 192
            ::.|..|||.:|:.|:|:|.....:|:|...|:...: |:|::.::::..:||:|.:.|...:.|
Human   138 RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETN 202

  Fly   193 AQ-NDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISER 256
            .| |....||.||:..:..|...|::......:.:|.|:......|.||  ||::.:||.:|.||
Human   203 CQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLS--RVLNQYTDTIIQER 265

  Fly   257 RETVRR-AKADGTYRPLSLGDAEIGSKSQMALLDILLQS-SINNQPLSDADIREEVDTFMFEGDD 319
            :::::. .|.|.|.:           :.....|||:|.: ..:....||.|:..||.||:..|.|
Human   266 KKSLQAGVKQDNTPK-----------RKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHD 319

  Fly   320 TTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVP 384
            |.::.:|..||.:|.:||.|:|..||::.:||..:|  :|..||.::.|....||||.||.|.||
Human   320 TLAASISWILYCLALNPEHQERCREEVRGILGDGSS--ITWDQLGEMSYTTMCIKETCRLIPAVP 382

  Fly   385 AIGRHAQKELEIGDK-TIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPF 448
            :|.|...|.|...|. |:||..::.|.::..|.:...:.:|..|.|.||.::.....:.:||:||
Human   383 SISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPF 447

  Fly   449 SAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPML---NFILRSASGINVGLR 504
            |||.:|||||:||::|:||.|:.:|..:.:.|  :..:|:.   :|||:..:|:.:.|:
Human   448 SAGSRNCIGQEFAMIELKVTIALILLHFRVTP--DPTRPLTFPNHFILKPKNGMYLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	150/476 (32%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	153/484 (32%)
		heme binding region	447..460		9/12 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850