Protein Alignment Cyp4d20 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 148/529 - (27%)
• Similarity: 261/529 - (49%)
• Gaps: 73/529 - (13%)

  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFD- 65
            |:.|   |::|:|.:.||.:...:  |:|..||||..:|..|..|. .::|.     |   |||
  Rat    12 WVLL---AVVLVLLYGFGTRTHGL--FKKQGIPGPKPLPFFGTVLN-YYMGL-----W---KFDV 62

  Fly    66 ----KYGKTFRFWILGES---LIYTKDLQYFETILSSTTLLEKGQLYEYLRPF-----LNDGLLV 118
                ||||   .|.|.:.   |....|.:..:.:|    :.|...::...|.|     :...:.|
  Rat    63 ECHKKYGK---IWGLFDGQMPLFAITDTEMIKNVL----VKECFSVFTNRRDFGPVGIMGKAISV 120

  Fly   119 STGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVIT 183
            |...:|...|.:.:..|....|:....:::::..::|..||: ..|| .|.:.:.....::||||
  Rat   121 SKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQ-EKGK-PVPVKEVFGAYSMDVIT 183

  Fly   184 EAAMGVQVNAQNDPDFPYIKALKSVVYIQ-PDRMFRFSRRYNWLFPLAAPLLHRQLLS------- 240
            ..:.||.|::.|:|..|:::..|.::.|. .|.:|...    .|||...|:.  ::|:
  Rat   184 STSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV----VLFPFLTPVY--EMLNICMFPKD 242

  Fly   241 DIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDAD 305
            .|.....|..::...|.::|::.:.|  :..|.: :|...||.:.           ::..|||.:
  Rat   243 SIEFFKKFVYRMKETRLDSVQKHRVD--FLQLMM-NAHNDSKDKE-----------SHTALSDME 293

  Fly   306 IREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLD 370
            |..:...|:|.|.:.|||.:|..|:::|.||:.|:::.||:.|.| |: .||.|...:.:::|||
  Rat   294 ITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRAL-PN-KAPPTYDTVMEMEYLD 356

  Fly   371 CVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLED 435
            .|:.||:||||....:.|..:|::||....:|..:.:.:..|..|||..::|:|..||||||.::
  Rat   357 MVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKE 421

  Fly   436 QEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGIN 500
            .:...:.:.|:||..||:||||.:||::.||:.::|||:.:...|..|...|    :..|..|:
  Rat   422 NKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIP----LKLSRQGL- 481

  Fly   501 VGLRPRKAL 509
              |:|.|.:
  Rat   482 --LQPTKPI 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	122/448 (27%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	127/460 (28%)