DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	178/531 - (33%)
Similarity:	271/531 - (51%)	Gaps:	67/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGA-ENIIGWVGEKF 64
            :|.:::...:|:|..:....:||: ||....:.|||.:..:.|..|:...||: :.::.|.
  Rat    15 LWASVVILMVIVLKLFSLLLRRQK-LARAMDSFPGPPTHWLFGHALEIQKLGSLDKVVSWA---- 74

  Fly    65 DKYGKTFRFW---ILGESLIYTKDLQYFETILSSTTLLEKG-----QLYEYLRPFLNDGLLVSTG 121
            .::......|   .:|...||..|  |.:.:.|      :|     .:|::...::..||||..|
  Rat    75 QQFPHAHPLWFGQFVGFLNIYEPD--YAKAVYS------RGDPKAADVYDFFLQWIGKGLLVLDG 131

  Fly   122 RKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAA 186
            .||...||:.|..||:.||:.||.|....:.:|:|...|.|....:.|:...|...|||.:.:..
  Rat   132 PKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCT 196

  Fly   187 MGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYN-----WLFPLAAPLLH-RQLLSDIRVM 245
            .|...:.....|..|..|:..:..:...|:..|  :|:     ||.|      | |:.|...::.
  Rat   197 FGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSF--QYHNDFIYWLTP------HGRRFLRACKIA 253

  Fly   246 HDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILL----QSSINNQPLSDADI 306
            ||.||:||.:|:..::..|.          ..:|..:..:..|||||    :|.|.   ||||::
  Rat   254 HDHTDEVIRQRKAALQDEKE----------RKKIQQRRHLDFLDILLGVRDESGIK---LSDAEL 305

  Fly   307 REEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDL---KY 368
            |.|||||||||.|||:||:|..||.:|.:||.||...||::.:||...|     .|..||   .|
  Rat   306 RAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDS-----FQWDDLAKMTY 365

  Fly   369 LDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERF 432
            |...:||..|||||||.:.|...|.:...| :::||.:.|.|.:|..||::..:|||..|.|.||
  Rat   366 LTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRF 430

  Fly   433 LEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISK-VLRF-YELLPLGEELK-PMLNFILR 494
            ..:...|.:.||::||||||:|||||:||:.||||:.:. :||| :.|.|....:| |.|  |||
  Rat   431 SPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQL--ILR 493

  Fly   495 SASGINVGLRP 505
            |.:||::.|:|
  Rat   494 SKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	163/484 (34%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	169/492 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750