DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	538	Identity:	168/538 - (31%)
Similarity:	263/538 - (48%)	Gaps:	72/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 W--LTLITGALIL--LLTWDFGRKRQRVLAFEKS-----AIPGPIS----------IPILGCGLQ 47
            |  |.|:..:|.|  :|||        :.||..:     ..|.|.|          :.....|||
Mouse    19 WQLLQLVGASLFLARILTW--------ICAFYDNYCRLRCFPEPPSRHWFWGHMSMVKNNEEGLQ 75

  Fly    48 AL----HLGAENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQL--YE 106
            .|    |...:..:.|:|..:.         ||  .||:.|   :...||.::..:...::  |.
Mouse    76 LLTERSHQFHDVHLCWIGPFYP---------IL--RLIHPK---FIGPILQASAAVAPKEMIFYG 126

  Fly   107 YLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKV-ADGKTAVDM 170
            :|:|:|.||||||.|.||...|.:.|.||||.:|:.|::..::..::|....::: ..|...:||
Mouse   127 FLKPWLGDGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAKWQRLTTKGTACLDM 191

  Fly   171 LKYVSLAALDVITEAAMGVQVNAQNDPDFPYIKA---LKSVVYIQPDRMFRFSRRYNWLFPLAAP 232
            |:::||..||.:.........|.|..|. .||.|   |.|::..:..:.|.:   .::|:...|.
Mouse   192 LEHISLMTLDSLQNCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQPFLY---LDFLYYCTAD 252

  Fly   233 LLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD----ILLQ 293
              .|:......::|:|||.||.|||.|:.....|...:          ||::...||    :||.
Mouse   253 --GRRFRKACDLVHNFTDAVIRERRRTLSSQNLDEFLK----------SKTKSKTLDFIDVLLLA 305

  Fly   294 SSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPV 358
            ...:.:.|||.|||.|.|||||.|.|||:|.:|..||.:|||||.|:|..:|:|.:|.......:
Mouse   306 KDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEI 370

  Fly   359 TQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFP 422
            ....|..|.:|...|||::||:|||..|.|...:::.:.| :.||..|...:.::..|.:...:|
Mouse   371 EWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGTDCVISIFGVHHNPEVWP 435

  Fly   423 DPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKP 487
            ||..:.|.||..:..|..:..|::||||||:|||||.||:.||||.::..|..:.:||..:|.:.
Mouse   436 DPEVYDPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRR 500

  Fly   488 MLNFILRSASGINVGLRP 505
            ....|||:..|:.:.:.|
Mouse   501 KPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	153/483 (32%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	157/492 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750