DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and CYP4Z1

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_835235.1	Gene:	CYP4Z1 / 199974	HGNCID:	20583	Length:	505	Species:	Homo sapiens

Alignment Length:	477	Identity:	140/477 - (29%)
Similarity:	242/477 - (50%)	Gaps:	38/477 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LQALHLGAENIIGW-VGEK--------------FDKYGKTFRFWILGESLIYTKDLQYFETILSS 95
            ::||||.......| .|.|              .:||......|:...::.::.....:..||..
Human    40 IRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLK 104

  Fly    96 TTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRK 160
            ....:....::.|..::..||:...|.||...|:|....|:..:|:.::.:|.....:|::...:
Human   105 RQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEE 169

  Fly   161 VADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDF-PYIKALKSVVYIQPDRMFRFSRRYN 224
            .....:.:::.::|||..||.|.:.|...|.:.|.|... .|:||:.::..|...||..|....:
Human   170 HIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234

  Fly   225 WLFPLAAPLLHRQLLSDI-RVMHDFTDKVISERRETVR-RAKADGTYRPLSLGDAEIGSKSQMAL 287
            .:|..::   ..|:.|.. :.:|.||:|||.:|:|::: :.|.|.|            .|.:...
Human   235 LVFKFSS---QGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTT------------QKRRWDF 284

  Fly   288 LDILLQS-SINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLG 351
            |||||.: |.|.:..|:||::.||.||||.|.|||||.:|..||.:|::||.|||..:|::.:||
Human   285 LDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349

  Fly   352 PDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAH 415
            ..:|  :|...|..:.|....|||.:|||.||..|.|...|.:...| :::||..::::.::..|
Human   350 DGSS--ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALH 412

  Fly   416 RDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLP 480
            .:..::.||..|.|.||..:..:..:.:|::|||||.:|||||.||::|.||.::..|..::|.|
Human   413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477

  Fly   481 -LGEELKPMLNFILRSASGINV 501
             .....:|:...:|:|.:||:|
Human   478 DHSRPPQPVRQVVLKSKNGIHV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	135/467 (29%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	136/470 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850