Protein Alignment Cyp4d20 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 140/477 - (29%)
• Similarity: 242/477 - (50%)
• Gaps: 38/477 - (7%)

  Fly    46 LQALHLGAENIIGW-VGEK--------------FDKYGKTFRFWILGESLIYTKDLQYFETILSS 95
            ::||||.......| .|.|              .:||......|:...::.::.....:..||..
Human    40 IRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLK 104

  Fly    96 TTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRK 160
            ....:....::.|..::..||:...|.||...|:|....|:..:|:.::.:|.....:|::...:
Human   105 RQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEE 169

  Fly   161 VADGKTAVDMLKYVSLAALDVITEAAMGVQVNAQNDPDF-PYIKALKSVVYIQPDRMFRFSRRYN 224
            .....:.:::.::|||..||.|.:.|...|.:.|.|... .|:||:.::..|...||..|....:
Human   170 HIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234

  Fly   225 WLFPLAAPLLHRQLLSDI-RVMHDFTDKVISERRETVR-RAKADGTYRPLSLGDAEIGSKSQMAL 287
            .:|..::   ..|:.|.. :.:|.||:|||.:|:|::: :.|.|.|            .|.:...
Human   235 LVFKFSS---QGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTT------------QKRRWDF 284

  Fly   288 LDILLQS-SINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLG 351
            |||||.: |.|.:..|:||::.||.||||.|.|||||.:|..||.:|::||.|||..:|::.:||
Human   285 LDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG 349

  Fly   352 PDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAH 415
            ..:|  :|...|..:.|....|||.:|||.||..|.|...|.:...| :::||..::::.::..|
Human   350 DGSS--ITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALH 412

  Fly   416 RDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLP 480
            .:..::.||..|.|.||..:..:..:.:|::|||||.:|||||.||::|.||.::..|..::|.|
Human   413 HNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP 477

  Fly   481 -LGEELKPMLNFILRSASGINV 501
             .....:|:...:|:|.:||:|
Human   478 DHSRPPQPVRQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	130/438 (30%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	133/451 (29%)