Protein Alignment Cyp4d20 and cyp-25A4

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_497779.1
• Gene: cyp-25A4 / 183248
• WormBaseID: WBGene00007967
• Length: 501
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 132/543 - (24%)
• Similarity: 233/543 - (42%)
• Gaps: 90/543 - (16%)

  Fly     1 MWLTLITGALILLLTWDFGRKRQRVLAFEKS-AIPGPISIPI--LGCGLQAL-----HLGAENII 57
            ::.|:||  .|....|    :|..:.....| .||||   |:  |...|..:     .||..:..
 Worm     9 IFFTIIT--FISYSIW----RRHAIFKLRSSIGIPGP---PVHWLWGNLNIIKDRVSRLGYNDTT 64

  Fly    58 GWVGEKFDKYGKTFRFWILGESLIYTKD---------LQYFETILSSTT--LLEKGQLYEYLRPF 111
            .|......|||..|..: .|..|..|..         :|.|.......|  :....|
 Worm    65 QWHPTLHTKYGPIFGLY-CGTQLHITVSEEEDIKEIFIQNFSNFSDRMTPDIFGMNQ-------- 120

  Fly   112 LNDGLLVST-GRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVS 175
            ||..||.:| ...|...|......|....::...|.:.....:.::.|::.:......|:.:...
 Worm   121 LNQSLLQNTYATGWKHTRSAIAPIFSTGKMKAMHETLVSKIDIFLEVLKEKSSSGQKWDIFENFQ 185

  Fly   176 LAALDVITEAAMGVQVNAQND-PDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLL 239
            ..:||:|.:.|..:..|.|.| .|..|::|.|.|..:        ..:.:|:.|::  |:..:|.
 Worm   186 SLSLDIIGKCAFAIDSNCQRDRTDLFYVQARKFVGAV--------DLKKSWILPVS--LILPELS 240

  Fly   240 SDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEI--------GSKSQMALLDILLQSSI 296
            ...|.::.|:|...:|              .||..|..::        |......||::|::...
 Worm   241 WLWRFLYKFSDLSAAE--------------LPLVKGLVDLYDRRRAGEGGNDSTDLLNLLIRRET 291

  Fly   297 NNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQA 361
            ..: ::..::.|....|:..|.:|||:.:..:.|.:|.:|.|||:::||:::.   ..:|.:...
 Worm   292 IGK-MTQREVIENCFAFLIAGYETTSTAMMFSAYLLAEYPIVQQKLYEEIKKT---KENAGLNYD 352

  Fly   362 QLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTI-----PANTSIYLVLYYAHRDANYF 421
            .:.::||||||.||::|.|||.    .|....:.:.|.||     |.::::.:..|..||:...:
 Worm   353 SIHNMKYLDCVYKESLRFYPPT----THFTNRVCLNDMTIRGQIYPEDSTLKVQPYTIHRNPANW 413

  Fly   422 PDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYE--LLPLGEE 484
            ..|..|:|||| |:.|:..::..::||..||:.|:|.:||.:|.|..|:|:|..:|  |:|....
 Worm   414 ESPDEFQPERF-ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELSLVPGDPP 477

  Fly   485 LKPMLNFIL---RSASGINVGLR 504
            :.|..|.::   ||...:|:.||
 Worm   478 MIPETNGVIFRPRSPVRLNLKLR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	110/463 (24%)
cyp-25A4	NP_497779.1	CYP3A-like	73..494	CDD:410678	112/462 (24%)