Protein Alignment Cyp4d20 and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 140/548 - (25%)
• Similarity: 240/548 - (43%)
• Gaps: 89/548 - (16%)

  Fly     1 MWLTLITGALILLLT---WDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALH----LGAENIIG 58
            |.|.:::..:|.:.|   :....:|:|....||..:.||.....||...|...    ||.::...
 Worm     1 MALLILSSLVISIFTFFIYIILARRERFKLREKIGLSGPEPHWFLGNLKQTAERKEKLGYDDANR 65

  Fly    59 WVGEKFDKYGKTFRFWILGESL------------IYTKDLQYFETILSSTTLLEKGQLYEYLRPF 111
            |..|..::||:||..: .|..:            ::.|:...|.. .|..::.|..||...|
 Worm    66 WFNELHEQYGETFGIY-YGSQMNIVISNEKDIKEVFIKNFSNFSD-RSVPSIYEANQLTASL--- 125

  Fly   112 LNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSL 176
                |:.|....|...|......|....::...|.::....:.:|.||:.|......|:......
 Worm   126 ----LMNSYSSGWKHTRSAIAPIFSTGKMKAMQETINSKVDLFLDILREKASSGQKWDIYDDFQG 186

  Fly   177 AALDVITEAAMGVQVNAQND-PDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLS 240
            ..||||.:.|..:..|.|.| .|..|:.|.|.:..|.    .|.|:      .:||.:|..:|.:
 Worm   187 LTLDVIGKCAFAIDSNCQRDRNDVFYVNAKKYISNID----IRHSK------IIAASVLLPELST 241

  Fly   241 DIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEI-----------------GSKSQMALL 288
            ..:.::.:|                       .|.||||                 ||.| :.||
 Worm   242 FWKALYKYT-----------------------PLADAEIPLVEGLSNVYERRRGGEGSDS-VDLL 282

  Fly   289 DILL-QSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGP 352
            .:|| :....::|::..::.|....|:..|.:|||:.:::..|.::::|.|||:::||   ::..
 Worm   283 KLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEE---IMEA 344

  Fly   353 DASAPVTQAQLQDLKYLDCVIKETMRLYPPV-PAIGRHAQKELEIGDKTIPANTSIYLVLYYAHR 416
            ..:..:|...:.::||||||.|||:|.|||| ..|.|..::::.|..:..|....:..:.:..||
 Worm   345 KENGGLTYDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCREDITIRGQFYPKGAIVVCLPHTVHR 409

  Fly   417 DANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPL 481
            :...:..|..|.|||| |:.|:..::..::||..||:.|:|.:||.:|.|..|.|:|..:||...
 Worm   410 NPENWDSPEEFHPERF-ENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFELKQF 473

  Fly   482 -GE-ELKPMLN-FILRSASGINVGLRPR 506
             || :|.|..| .|:|....:.:.|:||
 Worm   474 EGEADLIPDCNGVIMRPNDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	119/467 (25%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	120/468 (26%)