Protein Alignment Cyp4d20 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 536
• Identity: 144/536 - (26%)
• Similarity: 252/536 - (47%)
• Gaps: 92/536 - (17%)

  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIG-----WVG 61
            |:.|.|   ||:|.:.:|.....  .|:|..|.||..:|.:|           ||:.     |
  Rat    12 WMLLAT---ILVLLYLYGTSTHG--NFKKLGISGPKPLPFVG-----------NILAYRHGFW-- 58

  Fly    62 EKFD-----KYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPF-----LNDGL 116
             :||     |||..:.|:...:.::...|....:|:|    :.|....:...|.|     |...:
  Rat    59 -EFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVL----VKECYSTFTNRRSFGPAGILKKAI 118

  Fly   117 LVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDV 181
            .:|...:|...|.:.:..|....|:....|:::::.::|.|::..|:....:.|.......::||
  Rat   119 TLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDV 183

  Fly   182 ITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNW---------LFPLAAPLLHRQ 237
            ||..:.||.|::.|:|..|:::.:|.::            ::|:         |||...|:..
  Rat   184 ITGTSFGVNVDSLNNPQNPFVQKVKKLL------------KFNFLDPFFLSVILFPFLTPVFE-- 234

  Fly   238 LLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSI-----N 297
             ..||.|   |...|:...|.:|.|.|.:.....:         |.::..|.:::.|..     :
  Rat   235 -AFDITV---FPKDVMKFFRTSVERMKENRMQEKV---------KQRLDFLQLMINSQSSGDKES 286

  Fly   298 NQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ 362
            :|.|:|.:|..:...|:|.|.:||||.:|.|||.:|.||::|:::.:|:...| |: .||||...
  Rat   287 HQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PN-KAPVTYDV 349

  Fly   363 LQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSF 427
            |.:::|||.|:.||:||:|....:.|..:|::||....||..|.:.:..:..|:|...:|:|..|
  Rat   350 LVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEF 414

  Fly   428 RPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYEL-------LPLGEEL 485
            .||||.:..:...|.:.|:||..||:||||.:||::.||:.:.:||:.:..       :||....
  Rat   415 CPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRK 479

  Fly   486 K----PMLNFILRSAS 497
            |    |....|||:.|
  Rat   480 KGFFQPEKPIILRAVS 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	123/460 (27%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	122/457 (27%)