DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	144/536 - (26%)
Similarity:	252/536 - (47%)	Gaps:	92/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIG-----WVG 61
            |:.|.|   ||:|.:.:|.....  .|:|..|.||..:|.:|           ||:.     |
  Rat    12 WMLLAT---ILVLLYLYGTSTHG--NFKKLGISGPKPLPFVG-----------NILAYRHGFW-- 58

  Fly    62 EKFD-----KYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPF-----LNDGL 116
             :||     |||..:.|:...:.::...|....:|:|    :.|....:...|.|     |...:
  Rat    59 -EFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVL----VKECYSTFTNRRSFGPAGILKKAI 118

  Fly   117 LVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDV 181
            .:|...:|...|.:.:..|....|:....|:::::.::|.|::..|:....:.|.......::||
  Rat   119 TLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNPITMKDIFGAYSMDV 183

  Fly   182 ITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNW---------LFPLAAPLLHRQ 237
            ||..:.||.|::.|:|..|:::.:|.::            ::|:         |||...|:..
  Rat   184 ITGTSFGVNVDSLNNPQNPFVQKVKKLL------------KFNFLDPFFLSVILFPFLTPVFE-- 234

  Fly   238 LLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSI-----N 297
             ..||.|   |...|:...|.:|.|.|.:.....:         |.::..|.:::.|..     :
  Rat   235 -AFDITV---FPKDVMKFFRTSVERMKENRMQEKV---------KQRLDFLQLMINSQSSGDKES 286

  Fly   298 NQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ 362
            :|.|:|.:|..:...|:|.|.:||||.:|.|||.:|.||::|:::.:|:...| |: .||||...
  Rat   287 HQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PN-KAPVTYDV 349

  Fly   363 LQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSF 427
            |.:::|||.|:.||:||:|....:.|..:|::||....||..|.:.:..:..|:|...:|:|..|
  Rat   350 LVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEF 414

  Fly   428 RPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYEL-------LPLGEEL 485
            .||||.:..:...|.:.|:||..||:||||.:||::.||:.:.:||:.:..       :||....
  Rat   415 CPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRK 479

  Fly   486 K----PMLNFILRSAS 497
            |    |....|||:.|
  Rat   480 KGFFQPEKPIILRAVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	130/498 (26%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	130/498 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910