Protein Alignment Cyp4d20 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 119/486 - (24%)
• Similarity: 209/486 - (43%)
• Gaps: 102/486 - (20%)

  Fly    39 IPILGCGLQALHLGAENIIGWVGEKFDKYGKTFRFWILGESLIY--------------TKDLQYF 89
            ||.||   .|:..| ::.|.::...::|||..|.|.::|::..|              .:||. .
Human    74 IPFLG---HAIAFG-KSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLN-A 133

  Fly    90 ETILS--STTLLEKGQLYEYLRP-FLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHS 151
            |.:.|  :|.:..||..|:...| ||....::.:|          .:..|||   .:|.|:::.:
Human   134 EDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSG----------LNIAHFK---QHVSIIEKET 185

  Fly   152 SVMVDNLRKVADGKTAVDMLKYVSLAALDVIT--EAAMGVQVNAQNDPDFPYIKALKSVVYIQPD 214
            ....::..:  .|:..|    :.:|:.|.::|  ....|.::.:|.:         :.|..:..|
Human   186 KEYFESWGE--SGEKNV----FEALSELIILTASHCLHGKEIRSQLN---------EKVAQLYAD 235

  Fly   215 RMFRFSRRYNWLFPLAAPL--------LHRQLLSDIRVMHDFTDKVISERRET------VRRAKA 265
            ....||.. .||.|...||        .||::       .|...|.|.:||::      :.:...
Human   236 LDGGFSHA-AWLLPGWLPLPSFRRRDRAHREI-------KDIFYKAIQKRRQSQEKIDDILQTLL 292

  Fly   266 DGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALY 330
            |.||:                          :.:||:|.::...:...:..|..|:|:..:...:
Human   293 DATYK--------------------------DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGF 331

  Fly   331 AIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELE 395
            .:||...:|::.:.|.:.|.|.:. .|:|..||:||..||..||||:||.||:..:.|.|:....
Human   332 FLARDKTLQKKCYLEQKTVCGENL-PPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQT 395

  Fly   396 IGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKF 460
            :...|||....:.:......|..:.:.:.|.|.|:|:|:|.......||||||.||...|||:.|
Human   396 VAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENF 460

  Fly   461 AVLEMKVLISKVLRFYELLPLGEELKPMLNF 491
            |.:::|.:.|.:||.|| ..|.:...|.:|:
Human   461 AYVQIKTIWSTMLRLYE-FDLIDGYFPTVNY 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	110/457 (24%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	112/462 (24%)