Protein Alignment Cyp4d20 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 117/495 - (23%)
• Similarity: 202/495 - (40%)
• Gaps: 57/495 - (11%)

  Fly     5 LITGALILLL------TWDF----GRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGW 59
            |.|..|.|||      .||.    ||.|...|...    ||.:..|..|..||.:....:    :
Human    11 LCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLP----PGTMGFPFFGETLQMVLQRRK----F 67

  Fly    60 VGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKW 124
            :..|..|||..::..:.|...:..........||.....|........:|..|..|.|.:.....
Human    68 LQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSS 132

  Fly   125 H-ARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMG 188
            | .|:|:...||..:.||.||.::.......::  :.::.|:..:.:...|......:.....:|
Human   133 HKQRKKVIMRAFSREALECYVPVITEEVGSSLE--QWLSCGERGLLVYPEVKRLMFRIAMRILLG 195

  Fly   189 V--QVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPL--LHRQLLSDIRVMHDFT 249
            .  |:....|.:...::|.:.:.            |..:..|:..|.  |:|.:.:
Human   196 CEPQLAGDGDSEQQLVEAFEEMT------------RNLFSLPIDVPFSGLYRGMKA--------- 239

  Fly   250 DKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFM 314
            ..:|..|.|...|||..|    |...:|..|.|..:.||  :..|....:.|....:::.....:
Human   240 RNLIHARIEQNIRAKICG----LRASEAGQGCKDALQLL--IEHSWERGERLDMQALKQSSTELL 298

  Fly   315 FEGDDTTSSGVSHALYAIARHPEVQQRIFEELQR---VLGPDASAPVTQAQLQDLKYLDCVIKET 376
            |.|.:||:|..:..:..:..:|.|.|::.|||:.   :...:....:....|:.|||:.||||||
Human   299 FGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKET 363

  Fly   377 MRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHN 441
            :||.||||...|.|.|..|:....||...::...:...|..|..|.:...|.|:||:....:..:
Human   364 LRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDAS 428

  Fly   442 TFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRF--YELL 479
            .|:::||..|.::|:|::||.:.:|:...::.|.  ::||
Human   429 RFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	96/422 (23%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	102/447 (23%)