Protein Alignment Cyp4d20 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 148/501 - (29%)
• Similarity: 254/501 - (50%)
• Gaps: 51/501 - (10%)

  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWV--GEKF 64
            ||.|   |:.|:|.:.:|.:...:  |:|..||||..:|.||..| :...|.     |.  .|.:
Human    12 WLLL---AVSLILLYLYGTRTHGL--FKKLGIPGPTPLPFLGNAL-SFRKGY-----WTFDMECY 65

  Fly    65 DKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRP-----FLNDGLLVSTGRKW 124
            .||.|.:..:...:.::...|....:|:|    :.|...::...||     |:.:.:.::...:|
Human    66 KKYRKVWGIYDCQQPMLAITDPDMIKTVL----VKECYSVFTNRRPFGPVGFMKNAISIAEDEEW 126

  Fly   125 HARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVAD-GKTAVDMLKYVSLA-ALDVITEAAM 187
            ...|.:.:..|....|:..|.|:.::..|:|.|||:.|: ||...  ||:|..| ::||||..:.
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT--LKHVFGAYSMDVITSTSF 189

  Fly   188 GVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKV 252
            ||.:::.|:|..|:::..|.::...|...|..|.:   :||...|:|.   ..:|.|   |..||
Human   190 GVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIK---VFPFLTPILE---ALNITV---FPRKV 245

  Fly   253 ISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQS-----SINNQPLSDADIREEVDT 312
            ||...::|::.|.         |..:...|.::..|.:::.|     |..::.|||.::..:...
Human   246 ISFLTKSVKQIKE---------GRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSII 301

  Fly   313 FMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETM 377
            |:|.|.:||||.:|..:|.:|.||:|||::.:|:..|| |:.:.|.....|| |:|||.|:.||:
Human   302 FIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQ-LEYLDMVVNETL 364

  Fly   378 RLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNT 442
            ||:|....:.|..:|::||....||....:.:..|..|.|..|:.:|..|.||||.:..:...:.
Human   365 RLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDP 429

  Fly   443 FAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPM 488
            :.|.||.:||:||||.:||::.||:.:.:||:.:...|..|...|:
Human   430 YIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	126/433 (29%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	128/435 (29%)