Protein Alignment Cyp4d20 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 171/534 - (32%)
• Similarity: 270/534 - (50%)
• Gaps: 64/534 - (11%)

  Fly     2 W-LTLITG-----ALILLLTWDFGRKRQRVLAFEKSAIPGPISIP-ILGCGLQALHLG----AEN 55
            | |.|:.|     |.||..|:.|....:|:..|     |.|.... .||      |||    .|.
Human    19 WLLLLVVGASWLLARILAWTYAFYHNGRRLRCF-----PQPRKQNWFLG------HLGLVTPTEE 72

  Fly    56 IIGWVGEKFDKYGKTFRFWI-------------LGESLIYTKDLQYFETILSSTTLLEKGQLYEY 107
            .:..:.:....|.:.|..|:             :..|:|.|.|....:.|:          .|:.
Human    73 GLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIV----------FYKT 127

  Fly   108 LRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVA-DGKTAVDML 171
            |:|:|.||||:|.|.||...|::.|.||||.:|:.|::|..:.:::|....:::| :|.|.:|:.
Human   128 LKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVF 192

  Fly   172 KYVSLAALDVITEAAMGVQVNAQNDPDFPYIKA---LKSVVYIQPDRMFRFSRRYNWLFPLAAPL 233
            :::||..||.:.:.......|.|..|. .||.|   |.::|..:.::.||:.....:|.|..
Human   193 EHISLMTLDSLQKCIFSFDSNCQEKPS-EYITAIMELSALVVKRNNQFFRYKDFLYFLTPCG--- 253

  Fly   234 LHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQS-SIN 297
              |:.....|::|||||.||.|||.|:.....|...:      |:..||: :..:|:||.| ..|
Human   254 --RRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQ------AKAKSKT-LDFIDVLLLSEDKN 309

  Fly   298 NQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQ 362
            .:.|||.|||.|.|||||.|.|||:||:|..||.:|||||.|:|..:|:|.:|.......:....
Human   310 GKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDD 374

  Fly   363 LQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLS 426
            |..|.:|...:||::||:||:|...|...:::.:.| :.||......:.::..|.:.:.:|||..
Human   375 LAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEV 439

  Fly   427 FRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNF 491
            :.|.||..:..|..:..|::||||||:||||||||:.||||:::..|..:.:||...|.:.....
Human   440 YDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEI 504

  Fly   492 ILRSASGINVGLRP 505
            :||:..|:.:.:.|
Human   505 VLRAEDGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	150/451 (33%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	151/463 (33%)