DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	552	Identity:	173/552 - (31%)
Similarity:	271/552 - (49%)	Gaps:	82/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLTLITGA----LILLL---TWDFGRKRQRVLAFEKS-----AIPGPISIP----ILGCGLQALH 50
            ||.|...|    |:|||   :|...|...:...|.::     ..|.|   |    .||      |
Mouse    13 WLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQP---PKWNWFLG------H 68

  Fly    51 LG----AENIIGWVGEKFDKYGKTFRFWILGE--SLIYTKDLQYFETIL--SSTTLLEKGQLYEY 107
            ||    .|:.:..|......|.:.|..| ||.  .:|.........::|  |::..|::...|.:
Mouse    69 LGMITPTEHGLKEVTNLVATYPQGFMTW-LGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSF 132

  Fly   108 LRPFLNDGLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTA-VDML 171
            |:|:|.||||:|.|.||.:.|::.|.||||.:|:.||:|.:..:::|....:.:|.|.:| :|:.
Mouse   133 LKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQHLASGGSARLDVF 197

  Fly   172 KYVSLAALDVITEAAMGVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLH- 235
            :.:||..||.:.:.......|.|.:|. .||.|:..:..:       .::||:.|      |||
Mouse   198 ENISLMTLDSLQKCVFSFDSNCQENPS-EYISAILELSAL-------VTKRYHQL------LLHI 248

  Fly   236 ----------RQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLD- 289
                      |:......::|.|||.||.:||.|:          |....|..:.:|::...||
Mouse   249 DSLYQLTCSGRRFHKACHLVHSFTDAVIQDRRRTL----------PSKHEDDVLKAKAKSKTLDF 303

  Fly   290 ---ILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLG 351
               :||....:.:.|||.|||.|.|||||||.|||:||:|..||.:|||||.|:|..:|:|.:|.
Mouse   304 IDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLR 368

  Fly   352 PDASAPV-------TQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIY 408
            ...|..:       .:..|..|.:|...|||::||:|||..|.|...:::.:.| :.||......
Mouse   369 DRESTEIECSCAVFLRDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICI 433

  Fly   409 LVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVL 473
            :.::..|.:...:|||..:.|.||..:..:..:..|::||||||:|||||.||:.||||.::..|
Mouse   434 INIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTL 498

  Fly   474 RFYELLPLGEELKPMLNFILRSASGINVGLRP 505
            ..:.:||..:|.:.....|||:..|:.:.:.|
Mouse   499 LRFRVLPDDKEPRRKPELILRAEGGLWLRVEP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	157/494 (32%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	161/502 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845232
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750