DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d20 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	456	Identity:	146/456 - (32%)
Similarity:	241/456 - (52%)	Gaps:	44/456 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DKYGKTFRFWILGESLIYT-KDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHARR 128
            :.:...|..|..|.:...| .|..|.:.||..:.....| :|..|.|::..|||:..|:.|...|
Mouse    79 EHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRSDPKANG-IYRLLAPWIGYGLLLLNGQPWFQHR 142

  Fly   129 KIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQVNA 193
            ::.|.|||:.:|:.||:.|.....:|:|...::|...:::::.:::||..||.:.:.|...:.:.
Mouse   143 RMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSV 207

  Fly   194 QNDPDF-PYIKALKSV----------VYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHD 247
            |.|.:: .|::|:..:          ::.|.|.::|.|..            .|......::.||
Mouse   208 QVDGNYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSN------------GRLAKQACQLAHD 260

  Fly   248 FTDKVISERRETVRRAKADGTYRPLSLGDAE-IGSKSQMALLDILLQSSI-NNQPLSDADIREEV 310
            .||.||..|::.::           ..|:.| |..|.::..|||||.:.: |...:||.|:|.||
Mouse   261 HTDGVIKMRKDQLQ-----------DEGELENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEV 314

  Fly   311 DTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKE 375
            |||||||.|||:||||...||:|.|||.|||..||:|.:||..:|  :|...|..:.|....|||
Mouse   315 DTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSS--ITWDHLDQIPYTTMCIKE 377

  Fly   376 TMRLYPPVPAIGRHAQKELEIGD-KTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQG 439
            .:|||||||.|.|.....:...| :::|....:.|.:|..|.:...:|:|..|.|.||..|..:
Mouse   378 ALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPR- 441

  Fly   440 HNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEEL-KPMLNFILRSASGINVGL 503
             ::.:::|||.|.:||||::||:.|:||:::..|..:||||....: :|:...:|:|.:||.:.|
Mouse   442 -HSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHL 505

  Fly   504 R 504
            :
Mouse   506 K 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	141/443 (32%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	145/451 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750